猪脑中单胺氧化酶和α-甘油磷酸脱氢酶的分布
The distribution of monoamine oxidase and alpha-glycerophosphate dehydrogenase in pig brain.
作者信息
Tipton K F, Dawson A P
出版信息
Biochem J. 1968 Jun;108(1):95-9. doi: 10.1042/bj1080095.
Abstract
Activities of the enzymes monoamine oxidase (EC 1.4.3.4), alpha-glycerophosphate dehydrogenase (EC 1.1.99.5) and cytochrome oxidase (EC 1.9.3.1) were determined in homogenates and in the mitochondrial fraction prepared from individual regions of pig brain. The variation in the activity of alpha-glycerophosphate dehydrogenase paralleled that of cytochrome oxidase, but this was not the case with monoamine oxidase. The differences in the activities of the enzymes among homogenates of the various regions of the brain persisted in mitochondria prepared from these homogenates. The purification of these three enzymes paralleled each other when mitochondria were prepared, suggesting that the three enzymes are bound to the same particles.
摘要
测定了猪脑各个区域制备的匀浆和线粒体组分中，单胺氧化酶（EC 1.4.3.4）、α-甘油磷酸脱氢酶（EC 1.1.99.5）和细胞色素氧化酶（EC 1.9.3.1）的活性。α-甘油磷酸脱氢酶活性的变化与细胞色素氧化酶的变化平行，但单胺氧化酶并非如此。大脑不同区域匀浆中这些酶活性的差异，在由这些匀浆制备的线粒体中依然存在。当制备线粒体时，这三种酶的纯化过程相互平行，表明这三种酶与相同的颗粒结合。
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