Downie W W, Whaley K, Wright M A, Bell M A, Taylor A K
Br Med J. 1968 Nov 23;4(5629):487-9. doi: 10.1136/bmj.4.5629.487.
The adrenocorticotrophic activities of two synthetic polypeptides, Synacthen (Ciba) and DW 75 (Sandoz), were compared in two groups of patients having a variety of arthritic disorders. Compared with Synacthen, injected either intramuscularly or intravenously, intravenous DW 75 was found to have a longer duration of adrenocorticotrophic activity (measured by plasma 11-hydroxycorticosteroid levels) in both groups of patients, while intramuscularly administered DW 75 did not appear to be absorbed well.
在两组患有多种关节炎疾病的患者中，对两种合成多肽（新促皮质素（汽巴公司）和DW 75（山德士公司））的促肾上腺皮质活性进行了比较。与经肌肉注射或静脉注射的新促皮质素相比，发现静脉注射的DW 75在两组患者中具有更长的促肾上腺皮质活性持续时间（通过血浆11 - 羟皮质类固醇水平测定），而肌肉注射的DW 75似乎吸收不佳。
