两种合成多肽促肾上腺皮质激素活性的比较：新促皮质素和DW 75。
Comparison of the adrenocorticotrophic activities of two synthetic polypeptides: synacthen and DW 75.
作者信息
Downie W W, Whaley K, Wright M A, Bell M A, Taylor A K
出版信息
Br Med J. 1968 Nov 23;4(5629):487-9. doi: 10.1136/bmj.4.5629.487.
Abstract
The adrenocorticotrophic activities of two synthetic polypeptides, Synacthen (Ciba) and DW 75 (Sandoz), were compared in two groups of patients having a variety of arthritic disorders. Compared with Synacthen, injected either intramuscularly or intravenously, intravenous DW 75 was found to have a longer duration of adrenocorticotrophic activity (measured by plasma 11-hydroxycorticosteroid levels) in both groups of patients, while intramuscularly administered DW 75 did not appear to be absorbed well.
摘要
在两组患有多种关节炎疾病的患者中，对两种合成多肽（新促皮质素（汽巴公司）和DW 75（山德士公司））的促肾上腺皮质活性进行了比较。与经肌肉注射或静脉注射的新促皮质素相比，发现静脉注射的DW 75在两组患者中具有更长的促肾上腺皮质活性持续时间（通过血浆11 - 羟皮质类固醇水平测定），而肌肉注射的DW 75似乎吸收不佳。
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Br Med J. 1968 Nov 23;4(5629):487-9. doi: 10.1136/bmj.4.5629.487.
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本文引用的文献
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A RAPID TEST OF ADRENOCORTICAL FUNCTION.肾上腺皮质功能的快速检测
Lancet. 1965 Jan 30;1(7379):243-5. doi: 10.1016/s0140-6736(65)91526-6.
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TOTAL SYNTHESIS OF ADRENOCORTICOTROPHIC HORMONE.促肾上腺皮质激素的全合成
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Effect of the synthetic polypeptide beta-1-24 (Synacthen) on adrenocortical function.
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Synacthen Depot--Adrenal response in normal subjects and corticotrophin-treated patients.长效合成促肾上腺皮质激素——正常受试者及促肾上腺皮质激素治疗患者的肾上腺反应
Br Med J. 1968 Mar 2;1(5591):557-8. doi: 10.1136/bmj.1.5591.557.
6
Adrenocorticotrophic action of long-acting tetracosactrin compared with corticotrophin-gel.长效二十四肽促皮质素与促皮质素凝胶的促肾上腺皮质作用比较。
Br Med J. 1967 Nov 18;4(5576):391-4. doi: 10.1136/bmj.4.5576.391.
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Experientia. 1966 Aug 15;22(8):528-30. doi: 10.1007/BF01898672.
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