Fogelman I, Citrin D L, McKillop J H, Turner J G, Bessent R G, Greig W R
J Nucl Med. 1979 Feb;20(2):98-101.
We have compared bone scintigrams made with Tc-99m-tagged HEDP (1-hydroxyethylidene diphosphonate)and MDP (methylene diphosphonate), the former at 4 hr after injection, the latter at both 2 and 4 hr. In 17 patients with skeletal metastases, there was no significant difference in lesion count or scan quality between the 4-hr images. The tumor-to-bone ratio (T/B) was significantly higher with Tc-HEDP (p less than 0.02). Lesion detection rate and T/B ratios were both lower with Tc-MDP at 2 hr when compared with the 4-hr values for both Tc-HEDP (p less than 0.02, p less than 0.005) and Tc-MDP (p less than 0.02, p less than 0.01). The 4-hr Tc-MDP scan was of significantly higher quality than the 2 hr Tc-MDP scan (p less than 0.01). Although Tc-HEDP produces a higher T/B ratio at 4 hr, the present study does not suggest that either agent is superior in clinical practice.
我们比较了用99m锝标记的1-羟基亚乙基二膦酸盐（HEDP）和亚甲基二膦酸盐（MDP）所做的骨闪烁扫描图，前者在注射后4小时成像，后者在注射后2小时和4小时成像。在17例有骨转移的患者中，4小时图像的病灶计数或扫描质量无显著差异。99m锝标记的HEDP的肿瘤与骨比值（T/B）显著更高（p<0.02）。与99m锝标记的HEDP的4小时值（p<0.02，p<0.005）和99m锝标记的MDP的4小时值（p<0.02，p<0.01）相比，99m锝标记的MDP在2小时时的病灶检出率和T/B比值均较低。99m锝标记的MDP的4小时扫描质量显著高于2小时扫描质量（p<0.01）。虽然99m锝标记的HEDP在4小时时产生更高的T/B比值，但本研究并不表明这两种药物在临床实践中哪一种更具优势。
