发育中大鼠肾皮质的糖异生作用。
Gluconeogenesis in developing rat kidney cortex.
作者信息
Zorzoli A, Turkenkopf I J, Mueller V L
出版信息
Biochem J. 1969 Jan;111(2):181-5. doi: 10.1042/bj1110181.
Abstract
- Gluconeogenesis in developing rat kidney cortex was studied by assaying the activities of two enzymes, glucose 6-phosphatase and phosphoenolpyruvate carboxykinase, and by measuring glucose formation in tissue slices. 2. Glucose 6-phosphatase and phosphoenolpyruvate carboxykinase are present in late foetal (21-22-day-old) tissue and increase rapidly postnatally. Maximum activity of phosphoenolpyruvate carboxykinase occurs at 7 days of age, followed by a decline to the adult level. Glucose 6-phosphatase activity rises during the first 2 postnatal weeks and then declines. 3. Late foetuses synthesize glucose from both pyruvate and l-glutamate. The rate increases during the first 2 weeks to above adult levels. Synthesis is always higher from pyruvate than from glutamate. 4. The effect of 24hr. starvation was studied in perinatal animals. The results indicate that the ability to increase the rate of glucose synthesis as a result of starvation is not present at birth, but develops some time after the second postnatal day.
摘要
- 通过测定葡萄糖-6-磷酸酶和磷酸烯醇式丙酮酸羧激酶这两种酶的活性，并测量组织切片中的葡萄糖生成量，对发育中的大鼠肾皮质糖异生进行了研究。2. 葡萄糖-6-磷酸酶和磷酸烯醇式丙酮酸羧激酶存在于胎儿后期（21 - 22日龄）组织中，出生后迅速增加。磷酸烯醇式丙酮酸羧激酶的最大活性在7日龄时出现，随后下降至成年水平。葡萄糖-6-磷酸酶活性在出生后的前2周上升，然后下降。3. 晚期胎儿从丙酮酸和L-谷氨酸都能合成葡萄糖。在前2周内合成速率增加到高于成年水平。从丙酮酸合成的量总是高于从谷氨酸合成的量。4. 对围产期动物进行了24小时饥饿影响的研究。结果表明，出生时不存在因饥饿而提高葡萄糖合成速率的能力，但在出生后第二天后的某个时间发展起来。
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