Oswald N T, Cater D B
Br J Exp Pathol. 1969 Feb;50(1):84-96.
polysaccharide (endotoxin) was injected i.v. into rats bearing carrageenin-induced granulomas and transplanted hepatomas, and the vascular-permeability changes were studied by injecting Pelikan ink i.v. at various times after the endotoxin (or saline in the controls). When the ink was given at 0 or 1 hr. there was little difference between the treated rats and the controls. But when the ink was given 2 or more hr. after the endotoxin there was a marked increase of the carbon-lined capillaries and venules, compared with controls, in tumour, granuloma, glomeruli, adrenal cortex, lung, lymph-nodes and sometimes heart. The significance of these changes is discussed in relation to the Shwartzman phenomenon, Arthus reaction, and adrenaline-induced vascular spasm producing anoxia.
将多糖（内毒素）静脉注射到患有角叉菜胶诱导的肉芽肿和移植性肝癌的大鼠体内，并通过在内毒素（或对照组中的生理盐水）注射后的不同时间静脉注射派力肯墨水来研究血管通透性变化。当在0或1小时给予墨水时，处理组大鼠与对照组之间几乎没有差异。但在内毒素注射后2小时或更长时间给予墨水时，与对照组相比，在肿瘤、肉芽肿、肾小球、肾上腺皮质、肺、淋巴结，有时还有心脏中，衬有碳的毛细血管和小静脉明显增加。结合施瓦茨曼现象、阿瑟斯反应以及肾上腺素诱导的血管痉挛导致缺氧来讨论这些变化的意义。
