多瘤病毒转化细胞中的回复突变：再转化、诱导抗原与致瘤性。
Reversion in polyoma-transformed cells: retransformation, induced antigens and tumorigenicity.
作者信息
Marin G, MacPherson I
出版信息
J Virol. 1969 Feb;3(2):146-9. doi: 10.1128/JVI.3.2.146-149.1969.
Abstract
We studied the properties of two morphologically reverted cell clones isolated as chromosomal segregants from a "hybrid" clone of BHK 21/13 hamster fibroblasts, transformed with polyoma virus. Both clones were less tumorigenic than control transformed cells. They contained no detectable polyoma-specific complement-fixing antigen. Induced transplantation antigen also appeared to be lost or reduced. Both clones could be retransformed with polyoma virus, suggesting that their reversion is due to the loss of viral genes from the transformed cell.
摘要
我们研究了从用多瘤病毒转化的BHK 21/13仓鼠成纤维细胞“杂交”克隆中分离出的两个形态学上回复的细胞克隆的特性，这两个克隆是作为染色体分离体获得的。与对照转化细胞相比，这两个克隆的致瘤性均较低。它们不含可检测到的多瘤病毒特异性补体结合抗原。诱导移植抗原似乎也丧失或减少。这两个克隆都可以用多瘤病毒再次转化，这表明它们的回复是由于转化细胞中病毒基因的丢失所致。
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