多瘤病毒转化细胞中的回复突变：再转化、诱导抗原与致瘤性。
Reversion in polyoma-transformed cells: retransformation, induced antigens and tumorigenicity.
作者信息
Marin G, MacPherson I
出版信息
J Virol. 1969 Feb;3(2):146-9. doi: 10.1128/JVI.3.2.146-149.1969.
Abstract
We studied the properties of two morphologically reverted cell clones isolated as chromosomal segregants from a "hybrid" clone of BHK 21/13 hamster fibroblasts, transformed with polyoma virus. Both clones were less tumorigenic than control transformed cells. They contained no detectable polyoma-specific complement-fixing antigen. Induced transplantation antigen also appeared to be lost or reduced. Both clones could be retransformed with polyoma virus, suggesting that their reversion is due to the loss of viral genes from the transformed cell.
摘要
我们研究了从用多瘤病毒转化的BHK 21/13仓鼠成纤维细胞“杂交”克隆中分离出的两个形态学上回复的细胞克隆的特性，这两个克隆是作为染色体分离体获得的。与对照转化细胞相比，这两个克隆的致瘤性均较低。它们不含可检测到的多瘤病毒特异性补体结合抗原。诱导移植抗原似乎也丧失或减少。这两个克隆都可以用多瘤病毒再次转化，这表明它们的回复是由于转化细胞中病毒基因的丢失所致。
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本文引用的文献
1
Polyoma transformation of hamster cell clones--an investigation of genetic factors affecting cell competence.仓鼠细胞克隆的多瘤病毒转化——对影响细胞感受态的遗传因素的研究
Virology. 1962 Feb;16:147-51. doi: 10.1016/0042-6822(62)90290-8.
2
CELL-TRANSFORMING ABILITY OF A TEMPERATURE-SENSITIVE MUTANT OF POLYOMA VIRUS.多瘤病毒温度敏感突变体的细胞转化能力
Proc Natl Acad Sci U S A. 1965 Mar;53(3):486-91. doi: 10.1073/pnas.53.3.486.
3
Application of a microtechnique to viral serological investigations.一种微技术在病毒血清学研究中的应用。
J Immunol. 1962 Mar;88:320-9.
4
Selection of morphologically normal cell lines from polyoma-transformed BHK21/13 hamster fibroblasts.从多瘤病毒转化的BHK21/13仓鼠成纤维细胞中筛选形态正常的细胞系。
J Virol. 1968 Jan;2(1):69-77. doi: 10.1128/JVI.2.1.69-77.1968.
5
Viral DNA in polyoma- and SV40-transformed cell lines.多瘤病毒和SV40转化细胞系中的病毒DNA。
Proc Natl Acad Sci U S A. 1968 Apr;59(4):1158-65. doi: 10.1073/pnas.59.4.1158.
6
Loss of T-antigen from somatic hybrids between mouse cells and SV40-transformed human cells.小鼠细胞与SV40转化的人类细胞之间的体细胞杂种中T抗原的缺失。
Proc Natl Acad Sci U S A. 1968 Apr;59(4):1132-5. doi: 10.1073/pnas.59.4.1132.
7
Transformation of polyploid hamster cells by polyoma virus.
Nature. 1967 Oct 7;216(5110):62-3. doi: 10.1038/216062a0.
8
Virus-specific RNA in cells productively infected or transformed by polyoma virus.在被多瘤病毒有效感染或转化的细胞中的病毒特异性RNA。
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