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J Bacteriol. 1969 May;98(2):347-50. doi: 10.1128/jb.98.2.347-350.1969.
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10
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本文引用的文献

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SENSITIVITY OF COCCAL AND L FORMS OF STAPHYLOCOCCUS AUREUS TO FIVE ANTIBIOTICS.金黄色葡萄球菌球菌型和L型对五种抗生素的敏感性
J Bacteriol. 1964 Sep;88(3):630-2. doi: 10.1128/jb.88.3.630-632.1964.
3
Susceptibility of Proteus mirabilis and its stable L-forms to erythromycin and other macrolides.奇异变形杆菌及其稳定L型对红霉素和其他大环内酯类药物的敏感性。
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Inhibition by antibiotics of the growth of bacterial and yeast protoplasts.抗生素对细菌和酵母原生质体生长的抑制作用。
J Bacteriol. 1962 Sep;84(3):508-12. doi: 10.1128/jb.84.3.508-512.1962.
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[Antibacterial spectra of colistine for 1200 strains].[1200株菌株的黏菌素抗菌谱]
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6
The properties and mode of action of the polymyxins.多粘菌素的性质及作用方式。
Bacteriol Rev. 1956 Mar;20(1):14-27. doi: 10.1128/br.20.1.14-27.1956.
7
[Comparative sensitivity of normal and L forms of two strains of Proteus to some antibiotics].[两种变形杆菌菌株的正常形态与L型对某些抗生素的比较敏感性]
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8
Chemical, biological, and structural properties of stable Proteus L forms and their parent bacteria.变形杆菌稳定L型及其亲代细菌的化学、生物学和结构特性。
J Bacteriol. 1967 Mar;93(3):1143-59. doi: 10.1128/jb.93.3.1143-1159.1967.
9
The effects of antibiotics on the protoplast and bacterial forms of Streptococcus faecalis.抗生素对粪链球菌原生质体和细菌形态的影响。
J Lab Clin Med. 1966 Oct;68(4):543-51.
10
The 5'-nucleotidases (uridine diphosphate sugar hydrolases) of the Enterobacteriaceae.肠杆菌科的5'-核苷酸酶（尿苷二磷酸糖水解酶）
Biochemistry. 1968 Oct;7(10):3766-73. doi: 10.1021/bi00850a059.

青霉素G诱导的奇异变形杆菌L型和原生质体对多粘菌素B的敏感性。

Susceptibility to polymyxin B in penicillin G-induced Proteus mirabilis L forms and spheroplasts.

作者信息

Teuber M

出版信息

J Bacteriol. 1969 May;98(2):347-50. doi: 10.1128/jb.98.2.347-350.1969.

DOI:10.1128/jb.98.2.347-350.1969
PMID:4306537
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC284820/
Abstract

A polymyxin B-resistant strain of Proteus mirabilis was converted into L forms and spheroplasts in the presence of penicillin G. This treatment caused a 400-fold increase in polymyxin B susceptibility. The acquired susceptibility was in the range of the natural susceptibility reported for susceptible gram-negative bacteria ( approximately 1 mug/ml). The high susceptibility to polymyxin B was lost as soon as the spheroplasts and L forms were allowed to reconvert into the bacillary form in penicillin-free media. This behavior is strong evidence that the natural resistance of Proteus strains to polymyxins is due to the impermeability of the outer cell wall structures to these antibiotic substances.

摘要

一株奇异变形杆菌的多粘菌素B耐药菌株在青霉素G存在的情况下被转化为L型和原生质体。这种处理使多粘菌素B敏感性增加了400倍。获得的敏感性处于对敏感革兰氏阴性菌报道的天然敏感性范围内（约1微克/毫升）。一旦原生质体和L型在无青霉素的培养基中重新转化为杆菌形式，对多粘菌素B的高敏感性就会丧失。这种现象有力地证明，变形杆菌菌株对多粘菌素的天然耐药性是由于外细胞壁结构对这些抗生素物质的不透性所致。