新型β1 选择性肾上腺素能受体激动剂 H80/62，即（±）-1-（4-羟基苯氧基）-3-异丙氨基-2-丙醇诱发的唾液分泌。

Salivary secretion evoked by H80/62, (+/-)-1-(4-hydroxyphenoxy)-3-isopropylamino-2-propranol, a new beta 1-selective adrenoceptor agonist.

作者信息

Ekström J

出版信息

Acta Pharmacol Toxicol (Copenh). 1979 Oct;45(4):325-8. doi: 10.1111/j.1600-0773.1979.tb02400.x.

DOI:10.1111/j.1600-0773.1979.tb02400.x

Abstract

H80/62, recently introduced as a beta 1-selective adrenoceptor agonist, caused a long-lasting flow of saliva from parotid and submaxillary glands of the rat. The effect of H80/62 was prevented by propranolol or a beta 1-selective blocker. The drug did not exert its effect via the sympathetic postganglionic nerves; and it was not taken up by the neuronal amine pump. Sympathetically decentralized or denervated glands acquired a supersensitivity of the postjunctional type to H80/62.

摘要

H80/62是最近推出的一种β1选择性肾上腺素能受体激动剂，可使大鼠腮腺和颌下腺持续分泌唾液。普萘洛尔或β1选择性阻滞剂可阻断H80/62的作用。该药物并非通过交感神经节后神经发挥作用；且不被神经元胺泵摄取。交感神经去传入或去神经的腺体对H80/62产生了节后型超敏反应。