一种新型选择性β1肾上腺素能受体激动剂对大鼠腮腺淀粉酶分泌的影响。

Effects of a new selective beta1-adrenoceptor agonist on amylase secretion from the rat parotid gland.

作者信息

Carlsöö B, Danielsson A, Henriksson R

出版信息

Br J Pharmacol. 1978 Mar;62(3):364-6. doi: 10.1111/j.1476-5381.1978.tb08470.x.

DOI:10.1111/j.1476-5381.1978.tb08470.x

PMID:25100

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1668241/

Abstract

The effects of a new selective beta1-adrenoceptor agonist, (--)-1-(4-hydroxyphenoxy)-3-isopropyl-amino-propanol-2-hydrochloride (H 133/22), on amylase secretion from the rat parotid gland were investigated in an in vitro system. The results were compared to the secretory responses obtained with noradrenaline, adrenaline, methoxyamine and terbutaline. H 133/22 was found to be a potent enzyme secretagogue and appeared even more effective than noradrenaline and adrenaline, particularly at low concentrations. The beta1-adrenoceptor agonist, terbutaline, also stimulated amylase discharge from the parotid gland but was much less potent than H 133/22. Methoxyamine had no effect on enzyme secretion. We suggest that the adrenergic stimulation of amylase secretion from the rat parotid gland is mainly mediated by beta1-receptors.

摘要

在体外系统中研究了一种新型选择性β1-肾上腺素能受体激动剂（-）-1-（4-羟基苯氧基）-3-异丙氨基-丙醇-2-盐酸盐（H 133/22）对大鼠腮腺淀粉酶分泌的影响。将结果与用去甲肾上腺素、肾上腺素、甲氧明和特布他林获得的分泌反应进行比较。发现H 133/22是一种有效的酶促分泌剂，尤其在低浓度时，其效力似乎比去甲肾上腺素和肾上腺素更强。β1-肾上腺素能受体激动剂特布他林也刺激腮腺淀粉酶释放，但效力远低于H 133/22。甲氧明对酶分泌没有影响。我们认为，大鼠腮腺淀粉酶分泌的肾上腺素能刺激主要由β1受体介导。

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Amylase secretion from rat parotid glands as dependent on co-operation between sympathetic and parasympathetic nerves.大鼠腮腺淀粉酶的分泌取决于交感神经和副交感神经之间的协同作用。

Experientia. 1979 Oct 15;35(10):1336-7. doi: 10.1007/BF01963993.

本文引用的文献

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Body size and tissue respiration.身体大小与组织呼吸

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Differentiation of receptors responsive to isoproterenol.对异丙肾上腺素产生反应的受体的分化

Life Sci. 1967 Nov 1;6(21):2241-9. doi: 10.1016/0024-3205(67)90031-8.

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Differentiation of receptor systems activated by sympathomimetic amines.拟交感胺激活的受体系统的分化

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On the -adrenergic receptors in salivary glands of rat and dogs.关于大鼠和犬唾液腺中的β-肾上腺素能受体。

Experientia. 1972 Apr 15;28(4):420-1. doi: 10.1007/BF02008314.

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Techniques for measuring amylase secretion from pieces of mouse pancreas.测量小鼠胰腺组织淀粉酶分泌的技术。

Anal Biochem. 1974 May;59(1):220-34. doi: 10.1016/0003-2697(74)90028-1.

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2 new groups of selective stimulants of adrenergic beta-receptors.两类新型肾上腺素能β受体选择性兴奋剂。

Experientia. 1969 Sep 15;25(9):899-901. doi: 10.1007/BF01898049.

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Biochemical aspects of drug and hormone action on adipose tissue.药物和激素作用于脂肪组织的生化方面。

Pharmacol Rev. 1973 Mar;25(1):67-118.

8

Effect of adrenergic agents on alpha-amylase release and adenosine 3',5'-monophosphate accumulation in rat parotid tissue slices.肾上腺素能药物对大鼠腮腺组织切片中α-淀粉酶释放及3',5'-环磷酸腺苷积累的影响。

Biochim Biophys Acta. 1975 May 5;392(1):82-94. doi: 10.1016/0304-4165(75)90168-3.

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