细胞生长速率和细胞密度对鸡胚细胞中干扰素作用的影响。
Influence of the rate of cell growth and cell density on interferon action in chick embryo cells.
作者信息
Rossman T G, Vilcek J
出版信息
J Virol. 1969 Jul;4(1):7-11. doi: 10.1128/JVI.4.1.7-11.1969.
Abstract
Chick embryo cells became more sensitive to the action of interferon the longer they remained in culture. This phenomenon was found even before confluency had been reached. The relative insensitivity of newly seeded cells was not due to a loss of receptors. Cells synthesizing deoxyribonucleic acid (DNA) at a high rate were less sensitive to interferon action than cells synthesizing DNA at a low rate, but the inhibition of DNA synthesis had no effect on interferon action. An increase in the number of cells used for seeding resulted in an earlier appearance of increased sensitivity to interferon action. These results are discussed in relation to the induction process in animal cells.
摘要
鸡胚细胞在培养中停留的时间越长，对干扰素的作用就越敏感。甚至在达到汇合之前就发现了这种现象。新接种细胞的相对不敏感性并非由于受体的丧失。以高速率合成脱氧核糖核酸（DNA）的细胞对干扰素作用的敏感性低于以低速率合成DNA的细胞，但DNA合成的抑制对干扰素作用没有影响。用于接种的细胞数量增加导致对干扰素作用敏感性增加的出现更早。结合动物细胞中的诱导过程对这些结果进行了讨论。
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