Oppenheimer E H, Rosenstein B J
Lab Invest. 1979 Apr;40(4):445-9.
Nineteen nasal polyps from 13 patients were examined histologically. Nine polyps from seven cystic fibrosis (CF) patients could be positively identified by a triad of observations: delicate, barely visible basement membrane of surface epithelium without submucosal hyalinization, lack of extensive infiltration of eosinophils (Giemsa stains), and a preponderance of acid mucin in glands and cysts of the polyp and in its surface mucous blanket (Alcian Blue-periodic acid-Schiff stains). Two polyps from two patients with CF and atopy showed the characteristic findings of CF without modification. Eight polyps from four atopic patients without CF were identified by the reverse triad of changes: extensive thickening of the epithelial basement membrane and its extension into the submucosa as an irregular hyaline membrane, high stromal eosinophil count, and mainly neutral mucin in mucous glands, cysts, and mucous blanket. Hyperplastic mucous glands, mucous cysts of variable sizes, focal metaplasia of surface epithelium, and acid mucin in goblet cells were considered nonspecific lesions.
对13例患者的19个鼻息肉进行了组织学检查。通过三项观察结果可明确识别出7例囊性纤维化（CF）患者的9个息肉：表面上皮的基底膜 delicate、几乎不可见且无黏膜下透明变性，嗜酸性粒细胞浸润不广泛（吉姆萨染色），息肉的腺体、囊肿及其表面黏液层中酸性黏蛋白占优势（阿尔辛蓝-过碘酸希夫染色）。2例患有CF和特应性疾病的患者的2个息肉显示出CF的特征性表现且无改变。4例无CF的特应性患者的8个息肉通过相反的三联征变化得以识别：上皮基底膜广泛增厚并延伸至黏膜下层形成不规则透明膜，基质嗜酸性粒细胞计数高，黏液腺、囊肿和黏液层中主要为中性黏蛋白。黏液腺增生、大小不一的黏液囊肿、表面上皮的局灶化生以及杯状细胞中的酸性黏蛋白被视为非特异性病变。
