Martin G V, Heath R B
Br J Exp Pathol. 1969 Oct;50(5):516-9.
Experiments are described which indicate that equine rhinovirus infection of vervet monkeys can be used as an model of human rhinovirus infection. It is, however, shown that the equine rhinovirus has properties which are not typical of human rhinoviruses. The equine virus produced clinical signs in the monkeys and the infection could be estimated quantitatively by measuring the duration of virus excretion and the antibody response. The possible use of this rhinovirus model system for the testing of antiviral compounds is discussed.
文中描述的实验表明，黑长尾猴的马鼻病毒感染可作为人类鼻病毒感染的模型。然而，研究表明马鼻病毒具有一些并非人类鼻病毒典型特征的特性。马鼻病毒在猴子身上引发了临床症状，并且可以通过测量病毒排泄持续时间和抗体反应来对感染进行定量评估。本文还讨论了该鼻病毒模型系统在抗病毒化合物测试中的可能应用。
