Goldthorn J F, Schwartz A D
J Surg Oncol. 1979;11(1):53-7. doi: 10.1002/jso.2930110110.
The response to intravenous challenge with pneumococcus was examined in asplenic and sham-operated adult Sprague-Dawley rats eighteen weeks following surgery. The LD50 was over 2,0000 fold greater in the sham-operated animals than in the asplenic animals. These results suggest that the age of an asplenic host, the length of time following splenectomy, and the presence of a normal immune system other than the asplenic state do not in themselves confer immunity.
在手术18周后，对无脾和假手术的成年Sprague-Dawley大鼠进行了肺炎球菌静脉注射激发试验。假手术动物的半数致死量（LD50）比无脾动物高20000倍以上。这些结果表明，无脾宿主的年龄、脾切除后的时间长度以及除无脾状态外的正常免疫系统的存在本身并不能赋予免疫力。
