大鼠肝脏和肝癌中无活性核糖体成分的特性
Properties of the inactive ribosomal components in rat liver and hepatoma.
作者信息
Webb T E, Morris H P
出版信息
Biochem J. 1969 Nov;115(3):575-82. doi: 10.1042/bj1150575.
Abstract
- The relative concentrations of the inactive ribosomal components were compared in normal and regenerating rat liver and in two transplantable rat hepatomas (hepatomas 7800 and 5123D). 2. The size of the ribosomal-subunit pools in normal liver was not significantly affected by partial hepatectomy or neoplasia although, as shown previously, significant changes do occur in the monomer pool. 3. Further, the subunit pools in both liver and hepatoma were not significantly influenced by several treatments that caused dramatic changes in the size of the ribosomal monomer (and dimer) pools. 4. The high concentration of inactive monomers and dimers in the hepatomas appears to arise from limitations at the translational level, since they can be incorporated into pre-existing polyribosomes under the influence of cycloheximide.
摘要
- 比较了正常和再生大鼠肝脏以及两种可移植大鼠肝癌（肝癌7800和5123D）中无活性核糖体成分的相对浓度。2. 正常肝脏中核糖体亚基库的大小不受部分肝切除或肿瘤形成的显著影响，尽管如先前所示，单体库确实发生了显著变化。3. 此外，肝脏和肝癌中的亚基库不受几种导致核糖体单体（和二聚体）库大小发生显著变化的处理的显著影响。4. 肝癌中高浓度的无活性单体和二聚体似乎源于翻译水平的限制，因为它们可以在环己酰亚胺的影响下掺入预先存在的多核糖体中。
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