del Río Vázquez A, Carrera Carbó F, Arcocha Gilo V, Torrente Sierra J
Med Clin (Barc). 1979 Jan 25;72(2):71-3.
High doses of furosemide were given to patients with chronic renal failure who were on a program of dialysis with the aim of achieving less frequent dialysis or a more liberal diet for these patients. The result of the oral administration of 12 mg of bumetanide per day in 12 patients with renal insufficiency submitted to periodic hemodialysis were evaluated. The residual renal function of these patients varied between 1.5 and 6 ml/min of creatinine clearance. A significant variation could not be established in the predialysis values of urea, creatinine or potassium, nor of the interdialysis weight increase, nor of the urinary excretion of Na and K. On the contrary, the predialysis natremia levels varied from 133 to 138 mEq/l (p less than 0.01) under the effect of the medication and this coincided with a significant increase of the diuresis. As secondary effect the authors frequently recorded myalgia of variable intensity without significant changes in the serum enzymes of muscular origin.
对正在接受透析治疗的慢性肾衰竭患者给予大剂量呋塞米，目的是减少这些患者的透析频率或使其饮食更为宽松。评估了12例接受定期血液透析的肾功能不全患者每日口服12毫克布美他尼的效果。这些患者的残余肾功能在肌酐清除率1.5至6毫升/分钟之间变化。在透析前尿素、肌酐或钾的值、透析间期体重增加以及钠和钾的尿排泄方面均未发现显著变化。相反，在药物作用下，透析前血钠水平在133至138毫当量/升之间变化（p小于0.01），这与尿量显著增加相吻合。作为次要效应，作者经常记录到强度不等的肌痛，但肌肉源性血清酶无明显变化。
