Sánchez Rodriguez A, González Macías J, Díez Jarilla J L, González Villarón L, Bondía García-Puente M, Moreno de Vega V, de Castro del Pozo S
Med Clin (Barc). 1979 Feb 10;72(3):120-5.
A 49-year-old man presented medullary aplasia, sarcoidosis, and malacoplakia as evidenced by biopsy. This is apparently the first case of this association to be described in the literature. Medullary aplasia is basically an aplasia of the erythroid series, though it may be a pure aplasia of the red cells alone. A histologic study of the left testicle removed because of an infectious orchiepidydimitis led to the discovery of malacoplakia. Skin nodules appeared later; two of them were extirpated and revealed the existence of sarcoidosis. There was no evidence of sarcoidosis at any other level. The immune mechanism involved in pure red cell aplasia with or without thymoma are well known. The association of malacoplakia and sarcoidosis, two similar conditions, is closely related to alterations in cell immunity. The possibility that common immune factors were present in this patient. After eliminating different therapeutic approaches used in other cases, an immunosuppresive therapy was applied.
一名49岁男性经活检证实存在骨髓发育不全、结节病和软斑病。这显然是文献中描述的首例这种关联病例。骨髓发育不全基本上是红系发育不全，不过也可能仅是单纯的红细胞发育不全。对因感染性附睾炎切除的左侧睾丸进行组织学研究时发现了软斑病。之后出现了皮肤结节；切除了其中两个，发现存在结节病。在其他任何部位均未发现结节病迹象。伴有或不伴有胸腺瘤的纯红细胞再生障碍所涉及的免疫机制已为人熟知。软斑病和结节病这两种相似病症的关联与细胞免疫改变密切相关。该患者存在共同免疫因素的可能性。在排除其他病例中使用的不同治疗方法后，采用了免疫抑制疗法。
