Takatsuki A, Nakatani N, Morimoto M, Tamura G, Matsui M, Arima K, Yamaguchi I, Misato T
Appl Microbiol. 1969 Oct;18(4):660-7. doi: 10.1128/am.18.4.660-667.1969.
Rotenoids and related compounds were investigated for their effects on animal and plant viruses. Of 35 compounds examined, rotenone, rotenone norketone, acetylrotenone, acetylrotenone norketone, deguelin, deguelic acid, dehydrodeguelin, and isotubanol norketone, all used at low concentrations, suppressed the growth of Newcastle disease and herpes simplex viruses as determined by the agar diffusion, plaque inhibition method. Most of the compounds likewise decreased the number of necrotic spots on tobacco mosaic virus-infected leaf discs. Only derrisic acid completely inhibited the local lesion formation at subphytotoxic concentrations. Correlation of antiviral activity with respiratory inhibition of these compounds is discussed.
对鱼藤酮类化合物及相关化合物对动物和植物病毒的影响进行了研究。在所检测的35种化合物中，鱼藤酮、鱼藤酮降酮、乙酰鱼藤酮、乙酰鱼藤酮降酮、鱼藤素、鱼藤酸、脱氢鱼藤素和异巴豆醇降酮，均以低浓度使用，通过琼脂扩散法、蚀斑抑制法测定，它们均可抑制新城疫病毒和单纯疱疹病毒的生长。同样，大多数化合物也减少了感染烟草花叶病毒的叶盘上坏死斑的数量。只有鱼藤酸在低于植物毒性浓度时能完全抑制局部病斑的形成。本文讨论了这些化合物的抗病毒活性与呼吸抑制之间的相关性。
