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无细胞慢性淋巴细胞白血病。

Null cell chronic lymphocytic leukaemia.

作者信息

Forbes I J, Zalewski P D, Cowled P, Lander H, Sage R E, Dale B

出版信息

Med J Aust. 1979 Feb 10;1(3):72-4. doi: 10.5694/j.1326-5377.1979.tb112003.x.

DOI:10.5694/j.1326-5377.1979.tb112003.x
PMID:431434
Abstract

Lymphocytes lacking receptors for sheep erythrocytes and surface immunoglobulin were present in the blood in large numbers at some stage in four cases of chronic lymphocytic leukaemia (which included a mother and son), and formed a substantial proportion of the circulating lymphocytes in other cases. These null cells possessed receptors for mouse erythrocytes. Other B-cell markers were also found on these cells. Serial studies showed a great variation in the number of null cells during the course of the disease (which may be associated with treatment), suggesting variation in the the maturation of leukaemic cells, and indicating that the surface marker complement may not reflect the constitution of the cell undergoing the original malignant change.

摘要

在4例慢性淋巴细胞白血病患者(其中包括一对母子)病程的某些阶段,血液中大量存在缺乏绵羊红细胞受体和表面免疫球蛋白的淋巴细胞,在其他病例中这些细胞占循环淋巴细胞的相当比例。这些裸细胞具有小鼠红细胞受体。在这些细胞上还发现了其他B细胞标志物。系列研究表明,在疾病过程中(可能与治疗有关)裸细胞数量变化很大,提示白血病细胞成熟存在差异,也表明表面标志物补体可能无法反映发生原始恶性变化的细胞组成。

相似文献

1
Null cell chronic lymphocytic leukaemia.无细胞慢性淋巴细胞白血病。
Med J Aust. 1979 Feb 10;1(3):72-4. doi: 10.5694/j.1326-5377.1979.tb112003.x.
2
B cell leukaemia distinguished from chronic lymphocytic leukaemia by surface markers.
Aust N Z J Med. 1978 Oct;8(5):532-8. doi: 10.1111/j.1445-5994.1978.tb02595.x.
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Maturation of bone marrow lymphocytes. II. Development of Fc and complement receptors and surface immunoglobulin studied by rosetting and radioautography.骨髓淋巴细胞的成熟。II. 通过玫瑰花结形成试验和放射自显影术研究Fc和补体受体以及表面免疫球蛋白的发育
J Exp Med. 1978 Nov 1;148(5):1251-70. doi: 10.1084/jem.148.5.1251.
4
Increase in surface immunoglobulin-bearing cells and a relative decrease in complement receptor cells in chronic lymphocytic leukaemia.
S Afr Med J. 1979 Jan 27;55(4):132-7.
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Significance of mouse red cell rosette-forming lymphocytes in chronic lymphocytic leukaemia.小鼠红细胞花环形成淋巴细胞在慢性淋巴细胞白血病中的意义
Acta Haematol. 1978;60(1):36-44. doi: 10.1159/000207693.
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Rosette formation in chronic lymphocytic leukemia: studies of lymphocytes from peripheral blood and lymph node biopsy.慢性淋巴细胞白血病中的玫瑰花结形成:外周血和淋巴结活检淋巴细胞的研究
Isr J Med Sci. 1978 Dec;14(12):1268-70.
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[Rosette formation test with mouse erythrocytes in chronic lymphatic leukosis: correlation with other membrane receptors].[慢性淋巴细胞白血病中与小鼠红细胞的玫瑰花结形成试验:与其他膜受体的相关性]
Boll Ist Sieroter Milan. 1978 Nov 30;57(5):643-9.
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Study of cell-surface markers in chronic lymphocytic leukaemia (CLL).慢性淋巴细胞白血病(CLL)细胞表面标志物的研究。
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Prognostic significance of cell surface markers in childhood acute lymphoblastic leukaemia.儿童急性淋巴细胞白血病细胞表面标志物的预后意义
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