Forbes I J, Zalewski P D, Cowled P, Lander H, Sage R E, Dale B
Med J Aust. 1979 Feb 10;1(3):72-4. doi: 10.5694/j.1326-5377.1979.tb112003.x.
Lymphocytes lacking receptors for sheep erythrocytes and surface immunoglobulin were present in the blood in large numbers at some stage in four cases of chronic lymphocytic leukaemia (which included a mother and son), and formed a substantial proportion of the circulating lymphocytes in other cases. These null cells possessed receptors for mouse erythrocytes. Other B-cell markers were also found on these cells. Serial studies showed a great variation in the number of null cells during the course of the disease (which may be associated with treatment), suggesting variation in the the maturation of leukaemic cells, and indicating that the surface marker complement may not reflect the constitution of the cell undergoing the original malignant change.
在4例慢性淋巴细胞白血病患者(其中包括一对母子)病程的某些阶段,血液中大量存在缺乏绵羊红细胞受体和表面免疫球蛋白的淋巴细胞,在其他病例中这些细胞占循环淋巴细胞的相当比例。这些裸细胞具有小鼠红细胞受体。在这些细胞上还发现了其他B细胞标志物。系列研究表明,在疾病过程中(可能与治疗有关)裸细胞数量变化很大,提示白血病细胞成熟存在差异,也表明表面标志物补体可能无法反映发生原始恶性变化的细胞组成。