文献检索，用中文搜 PubMed

Suppr 超能文献

核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Veech R L, Raijman L, Krebs H A

Biochem J. 1970 Apr;117(3):499-503. doi: 10.1042/bj1170499.

The ratio [ATP]/[ADP][P(i)], as measured by direct determination of the three components in rat liver, was found in various nutritional states to have approximately the same value as the ratio [ATP]/[ADP][P(i)] calculated from the concentrations of lactate, pyruvate, glyceraldehyde phosphate and 3-phosphoglycerate on the assumption that lactate dehydrogenase, glyceraldehyde phosphate dehydrogenase and 3-phosphoglycerate kinase are at near-equilibrium in the liver. This implies that the redox state of the NAD couple in the cytoplasm is linked to, and partially controlled by, the phosphorylation state of the adenine nucleotides. 2. The combined equilibrium constant of the glyceraldehyde 3-phosphate dehydrogenase and 3-phosphoglycerate kinase reactions at 38 degrees C and I0.25, was found to be 5.9x10(-6). 3. The fall of the [NAD(+)]/[NADH] ratio in starvation and other situations is taken to be the consequence of a primary fall of the [ATP]/[ADP][HPO(4) (2-)] ratio.

通过直接测定大鼠肝脏中的三种成分所测得的[ATP]/[ADP][P(i)]比值，发现在各种营养状态下，其值与在假设乳酸脱氢酶、磷酸甘油醛脱氢酶和3-磷酸甘油酸激酶在肝脏中接近平衡的情况下，根据乳酸、丙酮酸、磷酸甘油醛和3-磷酸甘油酸的浓度计算得出的[ATP]/[ADP][P(i)]比值大致相同。这意味着细胞质中NAD偶联的氧化还原状态与腺嘌呤核苷酸的磷酸化状态相关联，并部分受其控制。2. 在38℃和I0.25条件下，磷酸甘油醛脱氢酶和3-磷酸甘油酸激酶反应的联合平衡常数为5.9×10⁻⁶。3. 在饥饿和其他情况下，[NAD⁺]/[NADH]比值的下降被认为是[ATP]/[ADP][HPO₄²⁻]比值原发性下降的结果。

Veech R L, Raijman L, Krebs H A

Biochem J. 1970 Apr;117(3):499-503. doi: 10.1042/bj1170499.

The ratio [ATP]/[ADP][P(i)], as measured by direct determination of the three components in rat liver, was found in various nutritional states to have approximately the same value as the ratio [ATP]/[ADP][P(i)] calculated from the concentrations of lactate, pyruvate, glyceraldehyde phosphate and 3-phosphoglycerate on the assumption that lactate dehydrogenase, glyceraldehyde phosphate dehydrogenase and 3-phosphoglycerate kinase are at near-equilibrium in the liver. This implies that the redox state of the NAD couple in the cytoplasm is linked to, and partially controlled by, the phosphorylation state of the adenine nucleotides. 2. The combined equilibrium constant of the glyceraldehyde 3-phosphate dehydrogenase and 3-phosphoglycerate kinase reactions at 38 degrees C and I0.25, was found to be 5.9x10(-6). 3. The fall of the [NAD(+)]/[NADH] ratio in starvation and other situations is taken to be the consequence of a primary fall of the [ATP]/[ADP][HPO(4) (2-)] ratio.

通过直接测定大鼠肝脏中的三种成分所测得的[ATP]/[ADP][P(i)]比值，发现在各种营养状态下，其值与在假设乳酸脱氢酶、磷酸甘油醛脱氢酶和3-磷酸甘油酸激酶在肝脏中接近平衡的情况下，根据乳酸、丙酮酸、磷酸甘油醛和3-磷酸甘油酸的浓度计算得出的[ATP]/[ADP][P(i)]比值大致相同。这意味着细胞质中NAD偶联的氧化还原状态与腺嘌呤核苷酸的磷酸化状态相关联，并部分受其控制。2. 在38℃和I0.25条件下，磷酸甘油醛脱氢酶和3-磷酸甘油酸激酶反应的联合平衡常数为5.9×10⁻⁶。3. 在饥饿和其他情况下，[NAD⁺]/[NADH]比值的下降被认为是[ATP]/[ADP][HPO₄²⁻]比值原发性下降的结果。