血管紧张素对人结肠的体外作用。
The action of angiotensin on the human colon in vitro.
作者信息
Fishlock D J, Gunn A
出版信息
Br J Pharmacol. 1970 May;39(1):34-9. doi: 10.1111/j.1476-5381.1970.tb09553.x.
Abstract
- The action of angiotensin on the circular and longitudinal muscle of the human colon has been studied in vitro. The ED50 value (g/ml) of circular muscle was 8.7 x 10(-8) and of longitudinal muscle 3.1 x 10(-8), while the corresponding figures for acetylcholine were 1.6 x 10(-6) and 1.1 x 10(-6), respectively. Angiotensin caused a sustained contraction associated with prolonged tachyphylaxis.2. As the action of angiotensin was not antagonized by atropine, hexa-methonium or procaine, angiotensin appeared to act directly on the smooth muscle of the human colon.3. Lidoflazine is not a specific antagonist of angiotensin.
摘要
已在体外研究了血管紧张素对人结肠环行肌和纵行肌的作用。环行肌的半数有效剂量（克/毫升）值为8.7×10⁻⁸，纵行肌为3.1×10⁻⁸，而乙酰胆碱的相应数值分别为1.6×10⁻⁶和1.1×10⁻⁶。血管紧张素引起持续收缩并伴有长时间快速耐受。
由于血管紧张素的作用不受阿托品、六甲铵或普鲁卡因的拮抗，血管紧张素似乎直接作用于人结肠的平滑肌。
利多氟嗪不是血管紧张素的特异性拮抗剂。
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