血管紧张素对肠道神经元件的刺激作用。
Stimulation of intestinal nervous elements by angiotensin.
作者信息
ROBERTSON P A, RUBIN D
出版信息
Br J Pharmacol Chemother. 1962 Aug;19(1):5-12. doi: 10.1111/j.1476-5381.1962.tb01423.x.
Abstract
The stimulation of nervous elements in the intestine by the polypeptide angiotensin has been examined. Comparisons between nicotine, a neurotropic agent, acetylcholine which exerts principally a musculotropic action and angiotensin have been made by examining their interactions with hexamethonium and the anticholinesterase 1,5-di-(p-N-allyl-N-methylaminophenyl)pentan-3-one dibromide in both the rabbit and guinea-pig ileum. The effect of atropine on the responses of the guinea-pig ileum and botulinum toxin on the responses of the rabbit ileum to angiotensin was also tested. The results show that angiotensin causes most of its contractile response in both the guinea-pig and rabbit ileum by an indirect action, through the stimulation of nervous tissue.
摘要
已对多肽血管紧张素对肠内神经元件的刺激作用进行了研究。通过在兔和豚鼠回肠中检测烟碱（一种亲神经剂）、主要发挥促肌作用的乙酰胆碱与血管紧张素分别与六甲铵和抗胆碱酯酶1,5 - 二 -（对 - N - 烯丙基 - N - 甲基氨基苯基）戊烷 - 3 - 酮二溴化物的相互作用，对它们进行了比较。还测试了阿托品对豚鼠回肠反应的影响以及肉毒杆菌毒素对兔回肠对血管紧张素反应的影响。结果表明，在豚鼠和兔回肠中，血管紧张素通过刺激神经组织的间接作用引起其大部分收缩反应。
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