多瘤病毒的宿主范围突变体。
Host range mutants of polyoma virus.
作者信息
Benjamin T L
出版信息
Proc Natl Acad Sci U S A. 1970 Sep;67(1):394-9. doi: 10.1073/pnas.67.1.394.
Abstract
A line of polyoma-transformed mouse cells has been isolated which is fully susceptible to lytic infection by polyoma virus. This line has been used to select virus mutants which have lost most or all of their ability to grow in the untransformed parental line while retaining the ability to grow in the transformed derivative. These virus mutants are also defective in their ability to transform cells of rat or hamster origin. Since the DNA extracted from the mutants has the same host range as the whole virus, the mutants appear to be blocked at some intracellular step which is required both for the completion of virus development in mouse cells and for transformation in rat or hamster cells.
摘要
已分离出一株多瘤病毒转化的小鼠细胞系，该细胞系对多瘤病毒的裂解感染完全敏感。此细胞系已用于筛选病毒突变体，这些突变体在未转化的亲代细胞系中大部分或全部丧失了生长能力，但在转化的衍生细胞系中仍保留生长能力。这些病毒突变体在转化大鼠或仓鼠来源的细胞的能力方面也存在缺陷。由于从突变体中提取的DNA与完整病毒具有相同的宿主范围，这些突变体似乎在某个细胞内步骤受阻，该步骤对于小鼠细胞中病毒发育的完成以及大鼠或仓鼠细胞中的转化都是必需的。
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