摘除眼球对雏鸡脑视叶中α-银环蛇毒素受体的影响。

Effects of eye removal on receptors of alpha-bungarotoxin in the optic lobes of chick brain.

作者信息

Kouvelas E D, Luckenbill-Edds L, LaVail J H, Greene L A

出版信息

Neurosci Lett. 1979 Jan;11(1):99-102. doi: 10.1016/0304-3940(79)90063-6.

Abstract

The existence of receptors with high affinity for alpha-bungarotoxin and the pharmacologic properties of a nicotinic ACh receptor has been shown in the optic tectum of chick brain. In the present study eyes were removed from chicks at embryonic day 3 (E3), or at post-hatching day 3 (P3). In both cases, the total number of receptors for I125-alphaBT which developed in the deafferented optic lobe was about 50% of the number in normal lobes.

摘要

在鸡脑视顶盖中已证实存在对α-银环蛇毒素具有高亲和力的受体以及烟碱型乙酰胆碱受体的药理特性。在本研究中，于胚胎第3天（E3）或孵化后第3天（P3）摘除雏鸡的眼睛。在这两种情况下，去传入神经的视叶中发育的I125-αBT受体总数约为正常视叶中受体数量的50%。