Lanza J P, Goude F, Lanza M
C R Seances Soc Biol Fil. 1979;173(4):797-806.
The effects of two neuroleptics (pipotiazine and fluphenazine) and five long-acting neuroleptics (pipotiazine undecylenate and palmitate, fluphenazine enanthate and decanoate, fluopentixol decanoate) are tested in the rat, during an observation period of 20 to 40 days following only one injection of compound. The compounds administered at three different and non toxic doses, are showing effects, the intensity and duration of which are different according to the dose and the compound: diestrus of pseudo-gestation or more than 15 days, hypertrophy of mammary gland, decreasing of the uterine weight. Some long-acting neuroleptics are active during more than forty days.
仅单次注射化合物后,在20至40天的观察期内,对两种抗精神病药(哌泊噻嗪和氟奋乃静)以及五种长效抗精神病药(哌泊噻嗪十一烯酸酯和棕榈酸酯、氟奋乃静庚酸酯和癸酸酯、氟哌噻吨癸酸酯)在大鼠身上的效果进行了测试。以三种不同的无毒剂量给药这些化合物,它们均显示出效果,其强度和持续时间根据剂量和化合物的不同而有所差异:假孕或超过15天的间情期、乳腺肥大、子宫重量减轻。一些长效抗精神病药在四十多天内都有活性。