Lee A E
Br J Cancer. 1970 Sep;24(3):568-73. doi: 10.1038/bjc.1970.69.
BR6 female mice treated with a mixture of hormones, developed mammary tumours earlier than untreated virgin animals. Implantation of ectopic pituitaries also increased tumour incidence and reduced the age at which tumours first appeared. This effect was obtained even in the absence of ovaries. Neither hormone treatment nor ectopic pituitaries succeeded in producing tumours as early as they appear in breeding females.
用激素混合物处理的BR6雌性小鼠比未处理的处女动物更早发生乳腺肿瘤。异位垂体移植也增加了肿瘤发生率,并降低了肿瘤首次出现的年龄。即使在没有卵巢的情况下也能获得这种效果。激素处理和异位垂体移植都不能像在繁殖雌性小鼠中那样早地诱发肿瘤。