Briand P, Thorpe S M, Daehnfeldt J L
Br J Cancer. 1977 Jun;35(6):816-21. doi: 10.1038/bjc.1977.123.
Administration of ovine prolactin alone supported growth of hormone-dependent GR mouse mammary tumours. Growth of hormone-independent tumours was not stimulated. Furthermore, administration of bromocriptine, a compound that inhibits release of prolactin from the pituitary gland, was shown to inhibit the growth of hormone-dependent tumours in animals receiving treatment with progesterone + oestrone. Administration of prolactin or bromocriptine to mice bearing tumours that grew independently of progesterone + oestrone treatment had no influence on tumour growth. We conclude that direct as well as indirect evidence has been found for the involvement of prolactin in the growth of transplanted, hormone-dependent GR mouse mammary tumours.
单独给予绵羊催乳素可支持激素依赖性GR小鼠乳腺肿瘤的生长。非激素依赖性肿瘤的生长未受到刺激。此外,给予溴隐亭(一种抑制垂体释放催乳素的化合物)可抑制接受孕酮+雌酮治疗的动物体内激素依赖性肿瘤的生长。对那些肿瘤生长独立于孕酮+雌酮治疗的小鼠给予催乳素或溴隐亭对肿瘤生长没有影响。我们得出结论,已发现直接和间接证据表明催乳素参与移植的、激素依赖性GR小鼠乳腺肿瘤的生长。