Kalden J R, Williamson W G, Irvine W J
Clin Exp Immunol. 1970 Apr;6(4):519-30.
Experimental thymitis and a partial neuromuscular block was produced in guinea-pigs by immunization with homologous thymus or skeletal muscle tissue in Freund's complete adjuvant. A boosting injection with the specific antigens 3 weeks after the initial immunization did not markedly increase the incidence of thymitis or of partial neuromuscular block. In animals with a partial neuromuscular block, thymectomy was followed by return of the muscle tetanus pattern to normal within 2–3 days. In contrast, the partial neuromuscular block persisted for 4 days after hemi-thymectomy and in some animals for as long as 10 days after sham thymectomy. These findings are in keeping with the hypothesis that experimentally induced thymitis may result in the release of a factor from the thymus which blocks neuromuscular transmission.
通过在弗氏完全佐剂中用同种胸腺或骨骼肌组织免疫豚鼠，可诱发实验性胸腺炎和部分神经肌肉阻滞。初次免疫3周后用特异性抗原进行加强注射，并未显著增加胸腺炎或部分神经肌肉阻滞的发生率。在出现部分神经肌肉阻滞的动物中，胸腺切除术后2 - 3天内肌肉破伤风模式恢复正常。相比之下，半胸腺切除术后部分神经肌肉阻滞持续4天，在一些动物中，假胸腺切除术后长达10天仍持续存在。这些发现与以下假设一致，即实验性诱导的胸腺炎可能导致胸腺释放一种阻断神经肌肉传递的因子。
