某些与局部麻醉剂结构相关的N-取代酰胺的合成及药理筛选。
Synthesis and pharmacological screening of certain N-substituted amides structurally related to some local anesthetics.
作者信息
El-Zahraa F, El-Basil S, El-Sayed M, Ghoneim K M, Khalifa M
出版信息
Pharmazie. 1979 Jan;34(1):12-3. doi: 10.1002/chin.197919213.
PMID:432249
Abstract
Diphenylacetyl chloride and pivaloyl chloride have been condensed with a wide variety of amines. Some of the resulting amides showed local anesthetic properties higher than those of procaine hydrochloride.
摘要
二苯乙酰氯和新戊酰氯已与多种胺类进行缩合反应。一些所得的酰胺表现出比盐酸普鲁卡因更高的局部麻醉性能。
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