长期乙醇喂养引起的多巴胺系统适应性变化。

Adaptive changes in the dopamine system produced by chronic ethanol feeding.

作者信息

Hoffman P L, Tabakoff B

出版信息

Drug Alcohol Depend. 1979 May-Jul;4(3-4):255-60. doi: 10.1016/0376-8716(79)90007-3.

Abstract

The consumption of ethanol by mice resulted in an altered sensitivity of the brain dopamine systems to perturbations produced by agonists and antagonists. The results indicate that ethanol feeding and withdrawal produces a state in which the normal coupling between dopamine receptors and the effectors for these receptors is significantly altered.

摘要

小鼠摄入乙醇会导致大脑多巴胺系统对激动剂和拮抗剂产生的干扰的敏感性发生改变。结果表明，给予乙醇和戒断乙醇会产生一种状态，即多巴胺受体与这些受体的效应器之间的正常偶联发生了显著改变。