Yacobi A, Krasula R W, Lai C M, Kamath B L
Res Commun Chem Pathol Pharmacol. 1979 Apr;24(1):197-200.
Six groups of rats received saline or N-Acetylprocainamide (NAPA) 2--50 mg/kg, intraperitoneally. Thirty minutes later heart rates were measured and simultaneously a blood sample was withdrawn from each rat. There was a linear relationship between plasma concentrations and the administered doses, suggesting linear pharmacokinetics for NAPA. The heart rate was decreased significantly when the average NAPA plasma concentration was 16.8 microgram/ml, which is similar to that found in man.
六组大鼠腹腔注射生理盐水或2-50毫克/千克的N-乙酰普鲁卡因胺（NAPA）。30分钟后测量心率，并同时从每只大鼠身上采集血样。血浆浓度与给药剂量之间存在线性关系，提示NAPA的药代动力学呈线性。当NAPA血浆平均浓度为16.8微克/毫升时，心率显著降低，这与在人体中发现的情况相似。
