苯丙胺和对氯苯丙胺的侧链单氟类似物。对大鼠纹状体中多巴胺和5-羟色胺释放的影响。
Side-chain monofluorinated analogs of amphetamine and p-chloroamphetamine. Effects on release of dopamine and 5-hydroxytryptamine from rat striatum.
作者信息
Coutts R T, Baker G B, Benderly A, McKim H R
出版信息
Res Commun Chem Pathol Pharmacol. 1979 Apr;24(1):201-4.
PMID:432436
Abstract
Monofluorinated analogs of (+/-)-amphetamine and (+/-)-p-chloroamphetamine, in which the methyl group was replaced with a monofluoromethyl group, have pKa values approximately 1.65 units lower than those of their amphetamine counter-parts but retain some ability to stimulate release of dopamine and 5-hydroxytryptamine, respectively, from rat corpus striatum.
摘要
（±）-苯丙胺和（±）-对氯苯丙胺的单氟类似物，其中甲基被单氟甲基取代，其pKa值比相应的苯丙胺类似物低约1.65个单位，但仍分别保留了一些从大鼠纹状体刺激释放多巴胺和5-羟色胺的能力。
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