（±）二羟基麻黄碱和（±）二羟基伪麻黄碱对肠系膜动脉肾上腺素能传递的影响
Effect of (plus or minus) dihydroxy ephedrine and (plus or minus) dihydroxy pseudoephedrine on adrenergic transmission in mesenteric arteries.
作者信息
Malik K U
出版信息
Br J Pharmacol. 1971 Feb;41(2):352-60. doi: 10.1111/j.1476-5381.1971.tb08036.x.
Abstract
- The effect of (+/-) dihydroxy ephedrine (DHE), (+/-) dihydroxy pseudoephedrine (DHPE) and isoprenaline on the vasoconstrictor responses of the perfused mesenteric arteries of the rat produced by stimulation of their periarterial sympathetic fibres, and in the responses to injected noradrenaline, has been studied.2. DHE and DHPE inhibited the responses to nerve stimulation and increased the responses to injected noradrenaline.3. Isoprenaline slightly decreased the basal perfusion pressure and reduced the responses to both nerve stimulation and injected noradrenaline. Since these effects of isoprenaline were abolished by propranolol, they are presumably mediated by beta-receptors.4. The inhibitory effect of DHE and DHPE on the responses to nerve stimulation was not abolished by propranolol.5. The results suggest that DHE and DHPE impair adrenergic transmission by partially replacing the adrenergic neurotransmitter, thereby acting as a false neurotransmitter.
摘要
研究了（±）二羟基麻黄碱（DHE）、（±）二羟基伪麻黄碱（DHPE）和异丙肾上腺素对大鼠灌注肠系膜动脉因刺激其动脉周围交感神经纤维所产生的血管收缩反应，以及对注射去甲肾上腺素反应的影响。
DHE和DHPE抑制对神经刺激的反应，并增强对注射去甲肾上腺素的反应。
异丙肾上腺素使基础灌注压略有降低，并减弱对神经刺激和注射去甲肾上腺素的反应。由于异丙肾上腺素的这些作用可被普萘洛尔消除，推测它们是由β受体介导的。
DHE和DHPE对神经刺激反应的抑制作用不能被普萘洛尔消除。
结果表明，DHE和DHPE通过部分取代肾上腺素能神经递质来损害肾上腺素能传递，从而起到假神经递质的作用。
相似文献
1
Effect of (plus or minus) dihydroxy ephedrine and (plus or minus) dihydroxy pseudoephedrine on adrenergic transmission in mesenteric arteries.（±）二羟基麻黄碱和（±）二羟基伪麻黄碱对肠系膜动脉肾上腺素能传递的影响
Br J Pharmacol. 1971 Feb;41(2):352-60. doi: 10.1111/j.1476-5381.1971.tb08036.x.
2
Modification by choline of adrenergic transmission in rat mesenteric arteries.胆碱对大鼠肠系膜动脉肾上腺素能传递的修饰作用。
Br J Pharmacol. 1971 Dec;43(4):776-83. doi: 10.1111/j.1476-5381.1971.tb07213.x.
3
Effect of sympathomimetic amines on the response of the perfused mesenteric artery preparation to adrenergic nerve stimulation.
Arzneimittelforschung. 1969 Sep;19(9):1574-9.
4
Modification by prostaglandins E1 and E2, indomethacin, and arachidonic acid of the vasoconstrictor responses of the isolated perfused rabbit and rat mesenteric arteries to adrenergic stimuli.前列腺素E1、E2、消炎痛和花生四烯酸对离体灌注兔和大鼠肠系膜动脉对肾上腺素能刺激的血管收缩反应的影响。
Circ Res. 1976 Aug;39(2):163-8. doi: 10.1161/01.res.39.2.163.
5
A possible antihypertensive mechanism of propranolol: antagonism of angiotensin II enhancement of sympathetic nerve transmission through prostaglandins.普萘洛尔可能的抗高血压机制：通过前列腺素拮抗血管紧张素II增强交感神经传递。
Hypertension. 1981 Jan-Feb;3(1):23-33. doi: 10.1161/01.hyp.3.1.23.
6
Prolonged treatment with (+/-) propranolol induces supersensitivity to (L)noradrenaline in mesenteric arteries in the rat.用（±）普萘洛尔进行长时间治疗会诱导大鼠肠系膜动脉对（L）去甲肾上腺素产生超敏反应。
Gen Pharmacol. 1985;16(5):463-8. doi: 10.1016/0306-3623(85)90005-9.
7
Raised tone reveals purinergic-mediated responses to sympathetic nerve stimulation in the rat perfused mesenteric vascular bed.升高的音调揭示了在大鼠灌注肠系膜血管床中嘌呤能介导的对交感神经刺激的反应。
Eur J Pharmacol. 2007 Jun 1;563(1-3):180-6. doi: 10.1016/j.ejphar.2007.02.011. Epub 2007 Feb 17.
8
Possible role of a beta-adrenoceptor in the regulation of noradrenaline release by nerve stimulation through a positive feed-back mechanism.β-肾上腺素能受体通过正反馈机制在神经刺激调节去甲肾上腺素释放中可能发挥的作用。
Br J Pharmacol. 1975 Jan;53(1):43-50. doi: 10.1111/j.1476-5381.1975.tb07328.x.
9
The effect of beta-adrenoreceptor antagonists on the inhibition of pendular movements of rabbit ileum produced by periarterial sympathetic nerve stimulation and some sympathomimetic amines.β-肾上腺素能受体拮抗剂对动脉周围交感神经刺激及某些拟交感胺类物质所引起的兔回肠摆动运动抑制作用的影响。
J Auton Pharmacol. 1986 Dec;6(4):311-7. doi: 10.1111/j.1474-8673.1986.tb00659.x.
10
Correlation of the directly observed responses of mesenteric vessles of the rat to nerve stimulation and noradrenaline with the distribution of adrenergic nerves.大鼠肠系膜血管对神经刺激和去甲肾上腺素的直接观察反应与肾上腺素能神经分布的相关性。
J Physiol. 1974 May;239(1):75-88. doi: 10.1113/jphysiol.1974.sp010556.
本文引用的文献
1
THE EFFECT OF SYMPATHETIC NERVE STIMULATION OF VASOCONSTRICTOR RESPONSES IN PERFUSED MESENTERIC BLOOD VESSELS OF THE RAT.大鼠肠系膜灌注血管中交感神经刺激对血管收缩反应的影响。
J Physiol. 1965 Mar;177(1):21-30. doi: 10.1113/jphysiol.1965.sp007572.
2
A hypothesis for the mode of action of alpha-methyldopa in relieving hypertension.关于α-甲基多巴缓解高血压作用机制的一种假说。
J Pharm Pharmacol. 1963 Apr;15:221-4. doi: 10.1111/j.2042-7158.1963.tb12778.x.
3
A fluorimetric method for the determination of dopamine (3-hydroxytyramine).一种测定多巴胺（3-羟基酪胺）的荧光分析法。
Acta Physiol Scand. 1958 Dec 15;44(3-4):293-8. doi: 10.1111/j.1748-1716.1958.tb01628.x.
4
Effects of dopamine and alpha-methyl-dopamine on smooth muscle and on the cardiac pacemaker.多巴胺和α-甲基多巴胺对平滑肌及心脏起搏器的作用。
J Pharmacol Exp Ther. 1967 May;156(2):310-24.
5
Effects of various autonomic drugs on isolated, perfused mesenteric arteries.各种自主神经药物对离体灌注肠系膜动脉的作用。
J Pharmacol Exp Ther. 1966 Feb;151(2):313-20.
6
The effect of vasodilator drugs on the noradrenaline constrictor response in the isolated mesenteric artery.
Can J Physiol Pharmacol. 1969 Aug;47(8):663-9. doi: 10.1139/y69-114.
7
Modification by acetylcholine of the response of rat mesenteric arteries to sympathetic stimulation.乙酰胆碱对大鼠肠系膜动脉交感神经刺激反应的调节作用。
Circ Res. 1969 Jul;25(1):1-9. doi: 10.1161/01.res.25.1.1.
8
Autonomic nervous system: newer mechanisms of adrenergic blockade.自主神经系统：肾上腺素能阻滞的新机制
Annu Rev Pharmacol. 1966;6:107-28. doi: 10.1146/annurev.pa.06.040166.000543.
9
[Functional importance of liberation of dihydroxyephedrine and dihydroxypseudoephedrine as "false" sympathetic transmitter substances in the heart].[二羟基麻黄碱和二羟基伪麻黄碱作为心脏中“假性”交感递质释放的功能重要性]
Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1967;256(1):1-25.
10
[Comparative study of the blood pressure effect, uptake and storage of dihydroxyephedrine (alpha-methyladrenaline) and dihydroxypseudoephedrine].
Naunyn Schmiedebergs Arch Pharmakol Exp Pathol. 1966;254(2):109-24.
Zotero 插件