分解代谢途径的特异性——从间接测定中学到的一课
Specificity of a catabolic pathway--a lesson learned from indirect assays.
作者信息
Ribbons D W, Ota Y, Higgins I J
出版信息
J Bacteriol. 1971 May;106(2):702-3. doi: 10.1128/jb.106.2.702-703.1971.
Abstract
Studies with purified orcinol hydroxylase suggest that, contrary to previous conclusions, the enzymes of the orcinol pathway cannot transform analogous compounds to common metabolites. The substrate analogues of orcinol uncouple electron flow from reduced nicotinamide adenine dinucleotide to oxygen from the hydroxylation reaction catalyzed by orcinol hydroxylase.
摘要
对纯化的苔黑酚羟化酶的研究表明，与先前的结论相反，苔黑酚途径的酶无法将类似化合物转化为常见代谢物。苔黑酚的底物类似物使电子流从还原型烟酰胺腺嘌呤二核苷酸到氧气的过程与苔黑酚羟化酶催化的羟基化反应解偶联。
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