Schorr I, Ney R L
J Clin Invest. 1971 Jun;50(6):1295-300. doi: 10.1172/JCI106608.
Properties of adenyl cyclase of normal adrenals and of a corticosterone-producing adrenal cancer of the rat have been compared. Enzyme activity was found in all particulate fractions of both tissues. The cyclase of the tumor as well as of the adrenals was stimulated by adrenocorticotropic hormone (ACTH) over similar concentration ranges. Unexpectedly, the tumor enzyme was also stimulated by epinephrine, norepinephrine, and thyroid-stimulating hormone (TSH). These hormones produced a dose-related effect over a concentration span that was comparable with that for ACTH. The tumor cyclase was not responsive to angiotensin Il, vasopressin, glucagon, insulin, growth hormone, parathyroid hormone, and thyrocalcitonin. ACTH was the only hormonal preparation that stimulated normal adrenal cyclase. These findings are compatible either with the possibility that the adenyl cyclase receptor of the tumor has undergone structural alteration with a consequent loss of specificity for ACTH or with the possibility that the tumor possesses several cyclase regulatory receptors.
已对正常肾上腺和大鼠一种产生皮质酮的肾上腺癌细胞的腺苷酸环化酶特性进行了比较。在两种组织的所有微粒部分均发现了酶活性。肿瘤和肾上腺的环化酶在相似的浓度范围内均受到促肾上腺皮质激素（ACTH）的刺激。出乎意料的是，肿瘤酶还受到肾上腺素、去甲肾上腺素和促甲状腺激素（TSH）的刺激。这些激素在与ACTH相当的浓度范围内产生剂量相关效应。肿瘤环化酶对血管紧张素II、血管加压素、胰高血糖素、胰岛素、生长激素、甲状旁腺激素和甲状腺降钙素无反应。ACTH是唯一能刺激正常肾上腺环化酶的激素制剂。这些发现要么与肿瘤的腺苷酸环化酶受体发生结构改变从而导致对ACTH特异性丧失的可能性相符，要么与肿瘤具有几种环化酶调节受体的可能性相符。
