1,25-二羟胆钙化醇：肠道中维生素D3活性形式的确认

1,25-dihydroxycholecalciferol: identification of the proposed active form of vitamin D3 in the intestine.

作者信息

Norman A W, Myrtle J F, Midgett R J, Nowicki H G, Williams V, Popják G

出版信息

Science. 1971 Jul 2;173(3991):51-4. doi: 10.1126/science.173.3991.51.

DOI:10.1126/science.173.3991.51

Abstract

The major polar metabolite of cholecalciferol (vitamin D(3)) present in chick intestinal mucosa has been chemically characterized by mass spectrometric analysis to have a molecular formula of C(27)H(44)0(3) and a structure of 1,25-dihydroxycholecalciferol. This compound, which is produced in the kidney from 25-hydroxycholecalciferol, has been previously shown to be from 4 to 13 times as active as cholecalciferol in stimulating intestinal calcium transport. 1,25-Dihydroxycholecalciferol (previously designated metabolite 4B in this (laboratory) probably represents the biologically active form of cholecalciferol in the intestine.

摘要

通过质谱分析对存在于雏鸡肠黏膜中的胆钙化醇（维生素D₃）的主要极性代谢产物进行了化学表征，其分子式为C₂₇H₄₄O₃，结构为1,25 - 二羟基胆钙化醇。这种化合物由肾脏中的25 - 羟基胆钙化醇产生，先前已表明其在刺激肠道钙转运方面的活性是胆钙化醇的4至13倍。1,25 - 二羟基胆钙化醇（本实验室先前称为代谢物4B）可能代表了胆钙化醇在肠道中的生物活性形式。