1,25-二羟胆钙化醇对肠道钙转运的作用机制
Mechanism of action of 1,25-dihydroxycholecalciferol on intestinal calcium transport.
作者信息
Tanaka Y, DeLuca H F, Omdahl J, Holick M F
出版信息
Proc Natl Acad Sci U S A. 1971 Jun;68(6):1286-8. doi: 10.1073/pnas.68.6.1286.
Abstract
The prior administration of actinomycin D prevents the metabolism of [(3)H]25-hydroxycholecalciferol to 1,25-dihydroxycholecalciferol, a metabolite of vitamin D(3) that is effective in the stimulation of intestinal calcium transport. In this paper, the question of whether the response of intestinal calcium transport to 1,25-dihydroxycholecalciferol is sensitive to actinomycin D was examined. While the response of intestinal transport to physiological amounts of 25-hydroxycholecalciferol is blocked by actinomycin D, the response of intestinal calcium transport to 1,25-dihydroxycholecalciferol is insensitive to the antibiotic. These results suggest that 1,25-dihydroxycholecalciferol, or a further metabolite thereof, is the metabolically active form of vitamin D in the intestine, that it functions by a process not involving transcription of DNA, and that the step sensitive to actinomycin D in the action of vitamin D on the intestine does not occur in the intestine, but is the conversion of 25-hydroxycholecalciferol to 1,25-dihydroxycholecalciferol in the kidney.
摘要
放线菌素D的预先给药可阻止[(3)H]25-羟基胆钙化醇代谢为1,25-二羟基胆钙化醇，后者是维生素D(3)的一种代谢产物，对刺激肠道钙转运有效。在本文中，研究了肠道钙转运对1,25-二羟基胆钙化醇的反应是否对放线菌素D敏感这一问题。虽然肠道转运对生理量的25-羟基胆钙化醇的反应被放线菌素D阻断，但肠道钙转运对1,25-二羟基胆钙化醇的反应对抗生素不敏感。这些结果表明，1,25-二羟基胆钙化醇或其进一步的代谢产物是维生素D在肠道中的代谢活性形式，其作用过程不涉及DNA转录，并且维生素D对肠道作用中对放线菌素D敏感的步骤不在肠道中发生，而是在肾脏中25-羟基胆钙化醇转化为1,25-二羟基胆钙化醇的过程。
相似文献
1
Mechanism of action of 1,25-dihydroxycholecalciferol on intestinal calcium transport.1,25-二羟胆钙化醇对肠道钙转运的作用机制
Proc Natl Acad Sci U S A. 1971 Jun;68(6):1286-8. doi: 10.1073/pnas.68.6.1286.
2
Regulation by calcium of in vivo synthesis of 1,25-dihydroxycholecalciferol and 21,25-dihydroxycholecalciferol.钙对体内1,25 - 二羟胆钙化醇和21,25 - 二羟胆钙化醇合成的调节作用。
Proc Natl Acad Sci U S A. 1971 Sep;68(9):2131-4. doi: 10.1073/pnas.68.9.2131.
3
The stimulation of 1,25-dihydroxycholecalciferol metabolism in vitamin D-deficient rats by 1,25-dihydroxycholecalciferol treatment.1,25 - 二羟胆钙化醇治疗对维生素D缺乏大鼠1,25 - 二羟胆钙化醇代谢的刺激作用。
J Clin Invest. 1973 Mar;52(3):543-8. doi: 10.1172/JCI107214.
4
Biological activity of 1alpha-hydroxycholecalciferol, a synthetic analog of the hormonal form of vitamin D3.1α-羟基胆钙化醇的生物活性，维生素D3激素形式的一种合成类似物。
Proc Natl Acad Sci U S A. 1973 Aug;70(8):2248-52. doi: 10.1073/pnas.70.8.2248.
5
5,6-Trans-25-hydroxycholecalciferol: vitamin D analog effective on intestine of anephric rats.5,6-反式-25-羟基胆钙化醇：对无肾大鼠肠道有效的维生素D类似物。
Science. 1972 Jun 16;176(4040):1247-8. doi: 10.1126/science.176.4040.1247.
6
Biologic effects of 1,25-dihydroxycholecalciferol (a highly active vitamin D metabolite) in acutely uremic rats.1,25-二羟胆钙化醇（一种高活性维生素D代谢产物）对急性尿毒症大鼠的生物学效应。
J Clin Invest. 1972 May;51(5):1287-91. doi: 10.1172/JCI106923.
7
1,25-dihydroxycholecalciferol: metabolite of vitamin D3 active on bone in anephric rats.1,25-二羟胆钙化醇：维生素D3的代谢产物，对无肾大鼠的骨骼有活性作用。
Science. 1972 Jun 9;176(4039):1146-7. doi: 10.1126/science.176.4039.1146.
8
Effects of cortisone administration on the metabolism and localization of 25-hydroxycholecalciferol in the rat.可的松给药对大鼠体内25-羟基胆钙化醇代谢及定位的影响。
J Clin Invest. 1973 Jun;52(6):1328-35. doi: 10.1172/JCI107304.
9
Role of 1,25-dihydroxycholecalciferol in calcification of bone and maintenance of serum calcium concentration in the rat.1,25-二羟胆钙化醇在大鼠骨骼钙化及血清钙浓度维持中的作用
J Nutr. 1972 Dec;102(12):1569-77. doi: 10.1093/jn/102.12.1569.
10
Vitamin D metabolism in experimental uraemia: effects on intestinal transport 45 Ca and on formation of 1,25-dihydroxycholecalciferol in rat.实验性尿毒症中的维生素D代谢：对大鼠肠道转运45钙及1,25 - 二羟胆钙化醇形成的影响
Nat New Biol. 1971 Aug 11;232(2):189-91. doi: 10.1038/newbio232189a0.
引用本文的文献
1
Physiological changes in the regulation of calcium and phosphorus utilization that occur after the onset of egg production in commercial laying hens.商品蛋鸡产蛋开始后钙和磷利用调节方面的生理变化。
Front Physiol. 2024 Sep 25;15:1465817. doi: 10.3389/fphys.2024.1465817. eCollection 2024.
2
Estradiol and Progesterone Levels are Related to Redox Status in the Follicular Fluid During Fertilization.受精期间卵泡液中的雌二醇和孕酮水平与氧化还原状态相关。
J Endocr Soc. 2020 Jun 1;4(7):bvaa064. doi: 10.1210/jendso/bvaa064. eCollection 2020 Jul 1.
3
Vitamin D and the intestine: Review and update.维生素 D 与肠道：综述与更新。
J Steroid Biochem Mol Biol. 2020 Feb;196:105501. doi: 10.1016/j.jsbmb.2019.105501. Epub 2019 Oct 23.
4
The clinical use of vitamin D metabolites and their potential developments: a position statement from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) and the International Osteoporosis Foundation (IOF).维生素D代谢物的临床应用及其潜在发展：来自欧洲骨质疏松症与骨关节炎临床与经济学会（ESCEO）和国际骨质疏松症基金会（IOF）的立场声明。
Endocrine. 2015 Sep;50(1):12-26. doi: 10.1007/s12020-015-0606-x. Epub 2015 May 1.
5
Alterations in vitamin D metabolite, parathyroid hormone and fibroblast growth factor-23 concentrations in sclerostin-deficient mice permit the maintenance of a high bone mass.硬骨素缺乏小鼠体内维生素D代谢物、甲状旁腺激素和成纤维细胞生长因子23浓度的改变有助于维持高骨量。
J Steroid Biochem Mol Biol. 2015 Apr;148:225-31. doi: 10.1016/j.jsbmb.2014.11.021. Epub 2014 Nov 22.
6
Reduced renal calcium excretion in the absence of sclerostin expression: evidence for a novel calcium-regulating bone kidney axis.在缺乏硬化蛋白表达的情况下肾钙排泄减少：一种新型钙调节骨-肾轴的证据
J Am Soc Nephrol. 2014 Oct;25(10):2159-68. doi: 10.1681/ASN.2014020166. Epub 2014 May 29.
7
Complementary and alternative medicine for the treatment of multiple sclerosis.补充和替代医学治疗多发性硬化症。
Expert Rev Clin Immunol. 2010 May;6(3):381-95. doi: 10.1586/eci.10.12.
8
Intestinal resistance to 1,25 dihydroxyvitamin D in mice heterozygous for the vitamin D receptor knockout allele.维生素D受体敲除等位基因杂合小鼠肠道对1,25-二羟维生素D的抵抗作用
Endocrinology. 2007 Mar;148(3):1396-402. doi: 10.1210/en.2006-1109. Epub 2006 Nov 16.
9
Jejunal and ileal adaptation to alterations in dietary calcium: changes in calcium and magnesium absorption and pathogenetic role of parathyroid hormone and 1,25-dihydroxyvitamin D.空肠和回肠对膳食钙变化的适应性：钙和镁吸收的变化以及甲状旁腺激素和1,25 - 二羟维生素D的致病作用
J Clin Invest. 1981 Jun;67(6):1599-603. doi: 10.1172/jci110194.
10
Oxygen-dependent 1,25-dihydroxycholecalciferol-induced calcium ion transport in rat intestine.氧依赖性1,25 - 二羟基胆钙化醇诱导的大鼠肠道钙离子转运
Biochem J. 1981 Jan 15;194(1):178-86. doi: 10.1042/bj1940178.
本文引用的文献
1
Actinomycin D Inhibition of Vitamin D Action.放线菌素 D 抑制维生素 D 作用。
Science. 1965 Jul 9;149(3680):182-4. doi: 10.1126/science.149.3680.182.
2
Biologically active metabolite of vitamin D3 from bone, liver, and blood serum.来自骨骼、肝脏和血清的维生素D3的生物活性代谢物。
J Lipid Res. 1966 Nov;7(6):739-44.
3
Influence of sodium on calcium transport by the rat small intestine.钠对大鼠小肠钙转运的影响。
Am J Physiol. 1969 Jun;216(6):1351-9. doi: 10.1152/ajplegacy.1969.216.6.1351.
4
The association of a metabolite of vitamin D3 with intestinal mucosa chromatin in vivo.维生素D3的一种代谢产物与体内肠黏膜染色质的关联。
J Biol Chem. 1968 Aug 10;243(15):4055-64.
5
On the relationship between vitamin D action and actinomycin-sensitive processes.关于维生素D作用与放线菌素敏感过程之间的关系。
Proc Natl Acad Sci U S A. 1966 Jan;55(1):177-84. doi: 10.1073/pnas.55.1.177.
6
Identification of 1,25-dihydroxycholecalciferol, a form of vitamin D3 metabolically active in the intestine.1,25-二羟胆钙化醇的鉴定，这是一种在肠道中具有代谢活性的维生素D3形式。
Proc Natl Acad Sci U S A. 1971 Apr;68(4):803-4. doi: 10.1073/pnas.68.4.803.
7
Metaboism of 25-hydroxycholecalciferol in target and nontarget tissues.25-羟胆钙化醇在靶组织和非靶组织中的代谢。
Biochemistry. 1970 Sep 15;9(19):3649-52. doi: 10.1021/bi00821a001.
8
Identification of 1,25-dihydroxycholecalciferol, a new kidney hormone controlling calcium metabolism.1,25-二羟胆钙化醇的鉴定，一种控制钙代谢的新型肾脏激素。
Nature. 1971 Mar 26;230(5291):228-30. doi: 10.1038/230228a0.
9
Inhibition of the metabolism of 25-hydroxycholecalciferol by actinomycin D and cycloheximide.放线菌素D和环己酰亚胺对25-羟基胆钙化醇代谢的抑制作用。
Proc Natl Acad Sci U S A. 1971 Mar;68(3):605-8. doi: 10.1073/pnas.68.3.605.
10
A rapidly acting metabolite of vitamin D3.维生素D3的一种快速起效的代谢产物。
Proc Natl Acad Sci U S A. 1971 Jan;68(1):177-81. doi: 10.1073/pnas.68.1.177.
Zotero 插件