Leary P M, Arens L, Marshall S, Schadle S
S Afr Med J. 1979 Mar 10;55(10):374-6.
The indications for the use of methylphenidate in 250 children are reviewed, and the effect of the drug is examined. Concentration was improved or hyperactive behaviour diminished in 89% of the children with normal intelligence and with no gross physical defect, in 72% of the children with cerebral palsy, and 68% of the children with subnormal intelligence. In children with emotional disturbance, response to methylphenidate was seldom satisfactory. Significant side-effects occurred infrequently and only 2 children lost weight during the period of medication.
回顾了250名儿童使用哌甲酯的适应症，并对该药的效果进行了检查。在智力正常且无明显身体缺陷的儿童中，89%的儿童注意力得到改善或多动行为减少；在脑瘫儿童中，这一比例为72%；在智力低于正常水平的儿童中，这一比例为68%。在有情绪障碍的儿童中，对哌甲酯的反应很少令人满意。明显的副作用很少发生，在用药期间只有2名儿童体重减轻。
