Lokich J J
Surg Gynecol Obstet. 1979 Apr;148(4):512-6.
The preoperative use of chemotherapy in the management of soft tissue sarcoma is a recent concept in the multidisciplinary management of neoplasia related to the development of more effective drug combinations. The reason for chemotherapy preoperatively is to define the effectiveness of drug treatment, permitting a rational basis for long term adjuvant treatment. In addition, major surgical morbidity may be precluded if chemotherapy is effective, allowing lesser surgical procedures, such as limb-sparing local resection. Patient selection for this approach must be individualized and is based upon the major determinants of prognosis, including the stage of the tumor according to the TNM and G--grade--classification. Radiation therapy is an essential component of the multimodality approach to soft tissue sarcomas, and the interaction of all three therapeutic modalities must provide optimal tumor control and minimal morbidity.
在软组织肉瘤的治疗中，术前使用化疗是肿瘤多学科管理中的一个新概念，这与更有效的联合药物的研发相关。术前进行化疗的原因是确定药物治疗的有效性，为长期辅助治疗提供合理依据。此外，如果化疗有效，可避免严重的手术并发症，从而允许采用较小的手术操作，如保肢局部切除术。这种治疗方法的患者选择必须个体化，并基于预后的主要决定因素，包括根据TNM分期和G分级分类的肿瘤分期。放射治疗是软组织肉瘤多模式治疗方法的重要组成部分，所有三种治疗方式的相互作用必须实现最佳的肿瘤控制并使发病率降至最低。
