Christou N V, Meakins J L
Surgery. 1979 May;85(5):543-8.
Cutaneous anergy to recall skin test antigens is associated with decreased polymorphonuclear neutrophil (PMN) chemotaxis (CTX). This decreased PMN chemotaxis is mediated by factors circulating in the sera (AS) from patients with anergy. Levamisole hydrochloride will correct the chemotactic defect of neutrophils from anergic patients, in vitro, from 96.2 +/- 1.2 to 125.1 +/- 1.7 microns at concentrations of 10(-3) M to 10(-18) M. Pretreatment of normal PMN with Levamisole at 10(-4) M will protect them from the chemotactic inhibiting effect of AS. Normal PMN migrating in the normal range, 128.1+/- 2.7 microns, can be made to behave like anergic PMN by treatment with AS. These PMN which now migrate in the anergic range 92.1 +/- 1.7 microns can be converted back to normal by Levamisole treatment at 10(-3) M to 10(-18) M. In 35 surgical patients who demonstrated the spectrum of decreased PMN CTX, the majority toward the anergy level, Levamisole improved the PMN CTX toward normal levels in every instance, while not affecting the CTX of the normally migrating PMN.
对回忆性皮肤试验抗原的皮肤无反应性与多形核中性粒细胞（PMN）趋化性（CTX）降低有关。这种PMN趋化性降低是由无反应性患者血清（AS）中循环的因子介导的。盐酸左旋咪唑在体外可将无反应性患者中性粒细胞的趋化缺陷从96.2±1.2微米校正至125.1±1.7微米，浓度范围为10⁻³M至10⁻¹⁸M。用10⁻⁴M左旋咪唑预处理正常PMN可使其免受AS的趋化抑制作用。正常PMN在正常范围内迁移，为128.1±2.7微米，用AS处理后可使其表现得像无反应性PMN。这些现在在无反应性范围内迁移的PMN，即92.1±1.7微米，通过10⁻³M至10⁻¹⁸M的左旋咪唑处理可恢复正常。在35例表现出PMN CTX降低范围（大多数趋向于无反应性水平）的外科患者中，左旋咪唑在每种情况下都将PMN CTX提高到正常水平，同时不影响正常迁移的PMN的CTX。
