Rabson A R, Anderson R, Glover A
Clin Exp Immunol. 1978 Jul;33(1):142-9.
Eighteen patients with primary abnormalities of neutrophil chemotaxis are described. The most common clinical presentation was one of recurrent upper respiratory tract infection (nine patients) or recurrent pyoderma (seven patients), and two children had a history of oropharyngeal candidiasis and recurrent skin sepsis. Of these eighteen patients, sixteen had intrinsic polymorphonuclear leucocyte (PMN) defects as shown by diminished random migration and movement towards endotoxin-activated serum. PMN chemotaxis towards casein was, however, normal. In nine out of the latter patients, there was an associated inability of the serum to generate chemotactic factors. PMN from two adult patients, both suffering from recurrent boils, moved normally both in random and directed systems, but sera from these patients contained heat-stable inhibitors of neutrophil chemotaxis. In vitro levamisole treatment (10(-3) M) markedly improved the PMN function. When patients were treated with levamisole, however, no clinical response was noted, although PMN movement improved in a number of cases.
本文描述了18例中性粒细胞趋化性原发性异常的患者。最常见的临床表现为反复上呼吸道感染（9例）或反复脓疱病（7例），两名儿童有口咽念珠菌病和反复皮肤脓毒症病史。在这18例患者中，16例存在内在的多形核白细胞（PMN）缺陷，表现为随机迁移和向内毒素激活血清的移动减少。然而，PMN对酪蛋白的趋化性正常。在其中9例患者中，血清同时存在产生趋化因子的能力缺陷。两名成年反复疖病患者的PMN在随机和定向系统中移动均正常，但这些患者的血清含有热稳定的中性粒细胞趋化抑制因子。体外左旋咪唑治疗（10⁻³ M）显著改善了PMN功能。然而，当患者接受左旋咪唑治疗时，尽管在一些病例中PMN移动有所改善，但未观察到临床反应。
