羟胺灭活对脊髓灰质炎病毒早期功能的影响。
Effect of inactivation by hydroxylamine on early functions of poliovirus.
作者信息
Borgert K, Koschel K, Täuber H, Wecker E
出版信息
J Virol. 1971 Jul;8(1):1-6. doi: 10.1128/JVI.8.1.1-6.1971.
Abstract
Evidence is presented that poliovirus particles with a single lethal hit by hydroxylamine do not induce in host cells either inhibition of cellular protein synthesis or viral ribonucleic acid (RNA) replication. The RNA of these viruses is not replicated even if the cells are simultaneously infected with both active and inactivated viruses. The damaged viral RNA seems to have lost both its template function and its function in the translation of normal viral proteins.
摘要
有证据表明，被羟胺单次致死性击中的脊髓灰质炎病毒颗粒不会在宿主细胞中诱导细胞蛋白质合成抑制或病毒核糖核酸（RNA）复制。即使细胞同时感染活性病毒和失活病毒，这些病毒的RNA也不会复制。受损的病毒RNA似乎既失去了其模板功能，也失去了在正常病毒蛋白翻译中的功能。
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