Vesely D L, Hadley M E
Science. 1971 Sep 3;173(4000):923-5. doi: 10.1126/science.173.4000.923.
The calcium ion is specifically required for the action of melanophorestimulating hormone on melanosome dispersion within lizard (Anolis carolinensis) melanophores in vitro. The response to this hormone is directly related to the concentration of the Ca(2+) ion. Lithium, choline, rubidium, and cesium will replace the sodium and potassium of Ringer solution if Ca(2+) is present. Calcium ions are not required for melanosome dispersion itself, since theophylline or dibutyryl cyclic adenosine monophosphate reversibly darkens lizard skins in the absence of calcium.
在体外，钙离子是促黑素细胞激素作用于蜥蜴（卡罗来纳安乐蜥）黑素细胞内黑素体分散所特需的。对这种激素的反应与Ca(2+)离子浓度直接相关。如果存在Ca(2+)，锂、胆碱、铷和铯会取代林格氏液中的钠和钾。黑素体分散本身并不需要钙离子，因为在没有钙的情况下，茶碱或二丁酰环磷酸腺苷可使蜥蜴皮肤可逆性变黑。
