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[放射性核素的促排研究:借助二乙三胺五乙酸(DTPA)对144铈(144Ce)的促排作用对其药代动力学进行研究(作者译)]

[Decorporation of radionuclides investigations on the pharmacokinetics of DTPA by means of its decorporating effect on 144Cer (author's transl)].

作者信息

Guhl L

出版信息

Strahlentherapie. 1979 Mar;155(3):216-9.

PMID:432895
Abstract

The influence of Zn-DTPA on the retention of 144Cer in several organs of the rat was investigated 4 days after 144Cer application either with intact or with prevented renal excretion. As the 144Cer activity mobilized from the liver is recovered in gut and faeces an excretion of DTPA bount 144Cer with the bile can be assumed. In animals with impeded renal function an amount of 144Cer is accumulated in blood and extracellular water which corresponds to that mobilized from the skeleton and is normally excreted with the urine.

摘要

研究了Zn-DTPA对144铈施用4天后在大鼠几个器官中潴留的影响,分别在肾脏排泄正常或受阻的情况下进行。由于从肝脏中动员出来的144铈活性在肠道和粪便中回收,因此可以推测DTPA结合的144铈会随胆汁排泄。在肾功能受损的动物中,一定量的144铈会在血液和细胞外液中蓄积,其数量与从骨骼中动员出来的量相当,正常情况下会随尿液排出。

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