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大鼠胃中微生物对烟酰胺的脱酰胺作用。

Nicotinamide deamidation by microorganisms in rat stomach.

作者信息

Shimoyama M, Tanigawa Y, Ito T, Murashima R, Ueda I, Tomoda T

出版信息

J Bacteriol. 1971 Oct;108(1):191-5. doi: 10.1128/jb.108.1.191-195.1971.

DOI:10.1128/jb.108.1.191-195.1971
PMID:4330735
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC247050/
Abstract

We have extended our investigation of nicotinamide deamidation in the stomach of conventional rats. The bacterial species in the pars preventricularis were identified as Flavobacterium peregrinum, Escherichia coli, Streptococcus faecalis, and Lactobacillus acidophilus, listed in order of decreasing deamidase activity. Nicotinamide-7-(14)C ingested into rat stomach was rapidly deamidated to nicotinic acid. These results contribute to the accumulated evidence that microorganisms present in the pars preventricularis of rat stomach are responsible for the deamidation of nicotinamide to nicotinic acid, a known precursor of mammalian pyridine nucleotides.

摘要

我们扩展了对普通大鼠胃中烟酰胺脱酰胺作用的研究。胃前庭部的细菌种类被鉴定为奇异黄杆菌、大肠杆菌、粪链球菌和嗜酸乳杆菌，按照脱酰胺酶活性递减的顺序列出。摄入大鼠胃中的烟酰胺-7-(14)C迅速脱酰胺生成烟酸。这些结果进一步证明，大鼠胃前庭部存在的微生物负责将烟酰胺脱酰胺生成烟酸，而烟酸是哺乳动物吡啶核苷酸的已知前体。

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Nicotinamide adenine dinucleotide biosynthesis and pyridine nucleotide cycle metabolism in microbial systems.微生物系统中的烟酰胺腺嘌呤二核苷酸生物合成与吡啶核苷酸循环代谢
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本文引用的文献

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NICOTINAMIDE DEAMIDASE FROM MAMMALIAN LIVER.来自哺乳动物肝脏的烟酰胺脱酰胺酶。
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STUDIES ON THE BIOSYNTHESIS OF NICOTINAMIDE ADENINE DINUCLEOTIDE. II. A ROLE OF PICOLINIC CARBOXYLASE IN THE BIOSYNTHESIS OF NICOTINAMIDE ADENINE DINUCLEOTIDE FROM TRYPTOPHAN IN MAMMALS.烟酰胺腺嘌呤二核苷酸生物合成的研究。II. 吡啶甲酸羧化酶在哺乳动物从色氨酸合成烟酰胺腺嘌呤二核苷酸中的作用
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THE ENZYMATIC CONVERSION OF QUINOLINATE TO NICOTINIC ACID MONONUCLEOTIDE IN MAMMALIAN LIVER.哺乳动物肝脏中喹啉酸向烟酰胺单核苷酸的酶促转化
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STUDIES ON THE BIOSYNTHESIS OF NICOTINAMIDE ADENINE DINUCLEOTIDE. I. ENZYMIC SYNTHESIS OF NIACIN RIBONUCLEOTIDES FROM 3-HYDROXYANTHRANILIC ACID IN MAMMALIAN TISSUES.烟酰胺腺嘌呤二核苷酸生物合成的研究。I. 哺乳动物组织中由3-羟基邻氨基苯甲酸酶促合成烟酸核糖核苷酸
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3-Hydroxyanthranilic acid as an intermediate in the oxidation of the indole nucleus of tryptophan.3-羟基邻氨基苯甲酸作为色氨酸吲哚核氧化过程中的一种中间体。
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Biosynthesis of diphosphopyridine nucleotide. III. Nicotinic acid mononucleotide pyrophos-phorylase.二磷酸吡啶核苷酸的生物合成。III. 烟酸单核苷酸焦磷酸化酶。
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Biosynthesis of diphosphopyridine nucleotide. I. Identification of intermediates.二磷酸吡啶核苷酸的生物合成。I. 中间产物的鉴定。
J Biol Chem. 1958 Aug;233(2):488-92.
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The non-identity of yeast nicotinic acid mononucleotide pyrophosphorylase and nicotinic acid mononucleotidase.酵母烟酸单核苷酸焦磷酸化酶与烟酸单核苷酸酶的不同一性。
Biochim Biophys Acta. 1966 May 5;118(2):422-4. doi: 10.1016/s0926-6593(66)80052-8.

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