大鼠胃中微生物对烟酰胺的脱酰胺作用。

Nicotinamide deamidation by microorganisms in rat stomach.

作者信息

Shimoyama M, Tanigawa Y, Ito T, Murashima R, Ueda I, Tomoda T

出版信息

J Bacteriol. 1971 Oct;108(1):191-5. doi: 10.1128/jb.108.1.191-195.1971.

DOI:10.1128/jb.108.1.191-195.1971

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC247050/

Abstract

We have extended our investigation of nicotinamide deamidation in the stomach of conventional rats. The bacterial species in the pars preventricularis were identified as Flavobacterium peregrinum, Escherichia coli, Streptococcus faecalis, and Lactobacillus acidophilus, listed in order of decreasing deamidase activity. Nicotinamide-7-(14)C ingested into rat stomach was rapidly deamidated to nicotinic acid. These results contribute to the accumulated evidence that microorganisms present in the pars preventricularis of rat stomach are responsible for the deamidation of nicotinamide to nicotinic acid, a known precursor of mammalian pyridine nucleotides.

摘要

我们扩展了对普通大鼠胃中烟酰胺脱酰胺作用的研究。胃前庭部的细菌种类被鉴定为奇异黄杆菌、大肠杆菌、粪链球菌和嗜酸乳杆菌，按照脱酰胺酶活性递减的顺序列出。摄入大鼠胃中的烟酰胺-7-(14)C迅速脱酰胺生成烟酸。这些结果进一步证明，大鼠胃前庭部存在的微生物负责将烟酰胺脱酰胺生成烟酸，而烟酸是哺乳动物吡啶核苷酸的已知前体。

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IDENTIFICATION OF HORMONES AFFECTING PYRIDINE NUCLEOTIDE METABOLISM OF RAT LIVER.影响大鼠肝脏吡啶核苷酸代谢的激素的鉴定

J Biol Chem. 1965 Jan;240:486-90.

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THE ENZYMATIC CONVERSION OF QUINOLINATE TO NICOTINIC ACID MONONUCLEOTIDE IN MAMMALIAN LIVER.哺乳动物肝脏中喹啉酸向烟酰胺单核苷酸的酶促转化

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