一种负责血管生成的肿瘤因子的分离。
Isolation of a tumor factor responsible for angiogenesis.
作者信息
Folkman J, Merler E, Abernathy C, Williams G
出版信息
J Exp Med. 1971 Feb 1;133(2):275-88. doi: 10.1084/jem.133.2.275.
Abstract
Human and animal solid tumors elaborate a factor which is mitogenic to capillary endothelial cells. This factor has been called tumor-angiogenesis factor. The important components of TAF are RNA and protein. It is suggested that blockade of this factor (inhibition of angiogenesis) might arrest solid tumors at a tiny diameter of a few millimeters.
摘要
人类和动物实体瘤可产生一种对毛细血管内皮细胞有促有丝分裂作用的因子。这种因子被称为肿瘤血管生成因子。肿瘤血管生成因子的重要成分是RNA和蛋白质。有人提出，阻断这种因子（抑制血管生成）可能会使实体瘤停滞在几毫米的微小直径状态。
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