O'Reilly K J
J Hyg (Lond). 1971 Dec;69(4):637-43. doi: 10.1017/s0022172400021914.
The propensity of an attenuated strain of feline infectious enteritis (panleucopaenia) virus to spread from vaccinated cats affected with intercurrent feline respiratory disease to unvaccinated in-contact cats was eradicated by further passaging of the vaccine virus in tissue culture. No virus was recovered from, and no antibody was found in the sentinel cats in contact with seven vaccinated animals. Thus, a further 27 passages of the vaccine virus in tissue culture has eliminated the spread factor.
通过在组织培养中对猫传染性肠炎(泛白细胞减少症)疫苗病毒进行进一步传代,消除了减毒株从感染并发猫呼吸道疾病的接种猫传播至未接种的接触猫的倾向。与7只接种动物接触的哨兵猫未检测到病毒,也未发现抗体。因此,疫苗病毒在组织培养中再传代27次后消除了传播因子。