Zierler H, Rosenkranz W, Winter R, Becker H
Wien Med Wochenschr. 1979 Apr 15;129(7):189-92.
In two pregnant women a prenatal diagnosis was performed because of their advanced age. In both cases trisomy 18 was found. The mothers had chromosomal variations, not known until then. In one woman a structural aberrant chromosome No. 9 was found, the other woman had a gonosomal mosaic. In connection with the advanced maternal age these chromosomal findings possibly induced the trisomies in the children.
两名高龄孕妇因年龄较大进行了产前诊断。在这两个病例中均发现了18三体综合征。两位母亲均有此前未知的染色体变异。其中一名女性发现了一条结构异常的9号染色体,另一名女性存在性染色体嵌合体。鉴于产妇年龄较大,这些染色体检查结果可能导致了胎儿的三体综合征。