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瑞士小鼠饮食诱导性心房血栓形成的光镜和电镜观察。II. 恢复正常饮食后的恢复情况

Light and electron microscopy of diet-induced atrial thrombosis in Swiss mice. II. Recovery on return to a balanced diet.

作者信息

Clower B R, Lockwood W R

出版信息

Am J Pathol. 1972 Jan;66(1):65-82.

PMID:4333121
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2032478/
Abstract

Diet-induced ultrastructural changes that occur in the atrial wall prior to thrombus formation are atrial subendothelial edema, endothelial vacuoles, damaged basement membrane and villous projections from endothelial (luminal surface) cells. Upon the return to a normal diet for 1-4 weeks, atrial edema is completely reversible, while the other ultrastructural alterations show minor or no signs of being repaired.

摘要

饮食诱导的在血栓形成之前心房壁发生的超微结构变化包括心房内皮下水肿、内皮细胞空泡、基底膜受损以及内皮（腔面）细胞的绒毛状突起。在恢复正常饮食1至4周后，心房水肿完全可逆，而其他超微结构改变显示出轻微的修复迹象或没有修复迹象。

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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45e1/2032478/7e9108a97f34/amjpathol00549-0101-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45e1/2032478/ae4b7b4617b6/amjpathol00549-0097-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45e1/2032478/702b081863d8/amjpathol00549-0097-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45e1/2032478/53bcb4d9d3c4/amjpathol00549-0102-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45e1/2032478/a3b7f6491667/amjpathol00549-0098-a.jpg

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本文引用的文献

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A RELIABLE AND EASILY SECTIONED EPOXY EMBEDDING MEDIUM.一种可靠且易于切片的环氧树脂包埋介质。
Anat Rec. 1964 Oct;150:129-39. doi: 10.1002/ar.1091500204.
2
The use of lead citrate at high pH as an electron-opaque stain in electron microscopy.在电子显微镜检查中，将高pH值的柠檬酸铅用作电子不透明染色剂。
J Cell Biol. 1963 Apr;17(1):208-12. doi: 10.1083/jcb.17.1.208.
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Cytochemistry and electron microscopy. The preservation of cellular ultrastructure and enzymatic activity by aldehyde fixation.细胞化学与电子显微镜术。醛类固定对细胞超微结构及酶活性的保存作用。
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Lesions in the rabbit aorta produced by feeding a high cholesterol diet followed by a normal diet. An electron microscopic study.通过先喂食高胆固醇饮食随后喂食正常饮食在兔主动脉中产生的病变。一项电子显微镜研究。
Br J Exp Pathol. 1962 Jun;43(3):236-40.
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Production of advanced cholesterol atherosclerosis in the rabbit.在兔子身上制造晚期胆固醇动脉粥样硬化。
Arch Pathol. 1960 Dec;70:712-24.
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Effects of varying the vehicle for OsO4 in tissue fixation.改变用于组织固定的四氧化锇载体的效果。
J Biophys Biochem Cytol. 1957 Sep 25;3(5):827-30. doi: 10.1083/jcb.3.5.827.
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The role of the endothelium in the initial phases of thrombosis. An electron microscopic study.内皮细胞在血栓形成初始阶段的作用。一项电子显微镜研究。
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8
Atherosclerosis in rabbits. Architectural and subcellular alterations of smooth muscle cells of aortas in response to hyperlipemia.兔动脉粥样硬化。高脂血症时主动脉平滑肌细胞的结构和亚细胞改变。
Exp Mol Pathol. 1966 Jun;5(3):273-310. doi: 10.1016/0014-4800(66)90036-0.
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Dietary-induced atrial thrombosis in mice.饮食诱导的小鼠心房血栓形成
Arch Pathol. 1965 Oct;80(4):391-6.
10
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J Atheroscler Res. 1968 Nov-Dec;8(6):885-90. doi: 10.1016/s0368-1319(68)80002-x.