Production of L-asparagine by tumor cells and the effect of asparagine analogs. - Suppr | 超能文献

Production of L-asparagine by tumor cells and the effect of asparagine analogs.

作者信息

Chou T C, Handschumacher R E

出版信息

Biochem Pharmacol. 1972 Jan;21(1):39-48. doi: 10.1016/0006-2952(72)90248-1.

DOI:10.1016/0006-2952(72)90248-1

Abstract

摘要

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Production of L-asparagine by tumor cells and the effect of asparagine analogs.

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2

Potential inhibitors of L-asparagine biosynthesis. 3. Aromatic sulfonyl fluoride analogs of L-asparagine and L-glutamine.L-天冬酰胺生物合成的潜在抑制剂。3. L-天冬酰胺和L-谷氨酰胺的芳基磺酰氟类似物。

J Med Chem. 1975 Sep;18(9):888-91. doi: 10.1021/jm00243a005.

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Studies on the mechanism of tumor inhibition by L-asparaginase. Effects of the enzyme on asparagine levels in the blood, normal tissues, and 6C3HED lymphomas of mice: differences in asparagine formation and utilization in asparaginase-sensitive and -resistant lymphoma cells.L-天冬酰胺酶抑制肿瘤机制的研究。该酶对小鼠血液、正常组织及6C3HED淋巴瘤中天冬酰胺水平的影响：天冬酰胺酶敏感及耐药淋巴瘤细胞中天冬酰胺生成与利用的差异。

J Exp Med. 1968 Jun 1;127(6):1055-72. doi: 10.1084/jem.127.6.1055.

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Asparagine biosynthesis by the Novikoff Hepatoma isolation, purification, property, and mechanism studies of the enzyme system.诺维科夫肝癌中天门冬酰胺生物合成：酶系统的分离、纯化、性质及机制研究

J Biol Chem. 1968 Jan 25;243(2):376-80.

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51 Cr-L-asparagine accumulation by tumors: the influence of L-asparaginase treatment.

J Nucl Biol Med. 1970 Oct-Dec;14(4):150-2.

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The population-dependent requirement by cultured mammalian cells for metabolites which they can synthesize. II. Glutamic acid and glutamine; aspartic acid and asparagine.培养的哺乳动物细胞对其自身能够合成的代谢物的群体依赖性需求。II. 谷氨酸和谷氨酰胺；天冬氨酸和天冬酰胺。

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Regeneration, tumor, dietary, and L-asparaginase effects on asparagine biosynthesis in rat liver.再生、肿瘤、饮食及L-天冬酰胺酶对大鼠肝脏中天冬酰胺生物合成的影响。

Cancer Res. 1969 Jun;29(6):1179-83.

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Asparagine biosynthesis in human KB tumor cells: inhibitor studies with asparagine and glutamine antagonists.人KB肿瘤细胞中天冬酰胺的生物合成：使用天冬酰胺和谷氨酰胺拮抗剂的抑制研究

Cancer Res. 1970 Apr;30(4):1081-3.

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Metabolism of asparagine, aspartate, glutamine, and glutamate in lymphoid tissue: basis for immunosuppression by L-asparaginase.淋巴组织中天冬酰胺、天冬氨酸、谷氨酰胺和谷氨酸的代谢：L-天冬酰胺酶免疫抑制作用的基础。

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New asparagine analogs.新型天冬酰胺类似物

J Med Chem. 1973 Nov;16(11):1277-80. doi: 10.1021/jm00269a012.

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Environ Health Perspect. 1973 Dec;6:137-43. doi: 10.1289/ehp.7306137.

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Enhanced plasma persistence of therapeutic enzymes by coupling to soluble dextran.

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Partial purification and properties of L-asparagine synthetase from mouse pancreas.小鼠胰腺L-天冬酰胺合成酶的部分纯化及性质

Biochem J. 1979 Jul 1;181(1):51-9. doi: 10.1042/bj1810051.