[关节炎支原体在实验性支原体感染中对小鼠和大鼠淋巴细胞的作用]

[Effect of Mycoplasma arthritidis on mouse and rat lymphoid cells in experimental Mycoplasma infection].

作者信息

Pronin A V, Sanin A V, Khorobrykh V V, Kaulen D R, Kagan G Ia

出版信息

Zh Mikrobiol Epidemiol Immunobiol. 1979 Mar(3):82-7.

Abstract

Early stages of mycoplasma infection of mice and rats were accompanied by suppression of the populations of rosette- and plaque-forming cells. Later the character and dynamics of the immune response to M. arthritidis differed in mice and rats. In mice mycoplasma infection was accompanied by stimulation of rosette-forming cells with some suppression of the plaque-forming cells from the 7th to the 36th day of infection. In rats by the 7th day the number of plaque- and rosette-forming cells decreased in comparison with control, and the immune response was restored by the 15h day; at later periods the immune response of the infected rats exceeded the normal level considerably. The cellular and humoral immune reactions proved to depend on the mycoplasma dose.

摘要

小鼠和大鼠支原体感染的早期阶段伴随着玫瑰花结形成细胞和噬斑形成细胞群体的抑制。后来，小鼠和大鼠对关节炎支原体免疫反应的特征和动态有所不同。在小鼠中，支原体感染伴随着玫瑰花结形成细胞的刺激，在感染的第7天至第36天，噬斑形成细胞受到一定抑制。在大鼠中，到第7天时，噬斑形成细胞和玫瑰花结形成细胞的数量与对照组相比减少，免疫反应在第15天时恢复；在后期，受感染大鼠的免疫反应大大超过正常水平。细胞免疫和体液免疫反应被证明取决于支原体剂量。